Abstract
We examined the association of the Diabetes Prevention Program (DPP) intervention arms (lifestyle intervention, metformin, and placebo) with cognition in the Diabetes Prevention Program Outcomes Study (DPPOS). We also examined metformin use, incident type 2 diabetes, and glycemia as exposures. The DPP lasted 2.8 years, followed by a 13-month bridge to DPPOS. Cognition was assessed in DPPOS years 8 and 10 (12 and 14 years after randomization) with the Spanish English Verbal Learning Test (SEVLT), letter fluency and animal fluency tests, Digit Symbol Substitution Test (DSST), and a composite cognitive score. A total of 2,280 participants (749 lifestyle, 776 metformin, and 755 placebo) aged 63.1 ± 10.7 years underwent cognitive assessments; 67.7% women, 54.6% non-Hispanic white, 20.7% non-Hispanic black, 14.6% Hispanic, 5.5% American Indian, and 4.6% Asian; 26.6% were homozygous or heterozygous for APOE-ε4. At the time of cognitive assessment, type 2 diabetes was higher in the placebo group (57.9%; P < 0.001) compared with lifestyle (47.0%) and metformin (50.4%). Metformin exposure was higher in the metformin group (8.72 years; P < 0.001) compared with placebo (1.43 years) and lifestyle (0.96 years). There were no differences in c...Continue Reading
References
May 8, 1998·Diabetes Care·M I HarrisD D Byrd-Holt
Mar 29, 2000·JAMA : the Journal of the American Medical Association·D J Selkoe
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Jul 19, 2001·Journal of the International Neuropsychological Society : JINS·H M GonzálezM N Haan
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Mar 28, 2002·Diabetes·Rita PeilaUNKNOWN Honolulu-Asia Aging Study
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Silva A ArslanianRola Saad
Dec 7, 2002·CNS Drugs·G Stennis Watson, Suzanne Craft
Sep 30, 2003·Diabetes·Matti UusitupaUNKNOWN Finnish Diabetes Prevention Study Group
Apr 20, 2005·Annals of Internal Medicine·Trevor J OrchardUNKNOWN Diabetes Prevention Program Research Group
Apr 28, 2005·Diabetes·Steven HaffnerUNKNOWN Diabetes Prevention Program Research Group
Jul 28, 2005·Diabetes·Abbas E KitabchiUNKNOWN Diabetes Prevention Program Research Group
Jan 16, 2008·Archives of Neurology·Fumiko IrieLenore J Launer
Oct 10, 2008·The New England Journal of Medicine·John Chalmers, Mark E Cooper
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yaomin ChenFrancesca-Fang Liao
Nov 3, 2009·Lancet·William C KnowlerDavid M Nathan
Apr 24, 2010·Journal of Alzheimer's Disease : JAD·José A Luchsinger
Feb 1, 2011·Neuropharmacology·Amit GuptaChinmoy Sankar Dey
Feb 8, 2011·Journal of Alzheimer's Disease : JAD·Chih-Cheng HsuHsin-Ni Tsai
Oct 1, 2011·Lancet Neurology·Lenore J LaunerUNKNOWN ACCORD MIND investigators
Nov 22, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yuji IshibashiSho-ichi Yamagishi
Mar 20, 2012·Pharmacology, Biochemistry, and Behavior·Jiejie LiZhiyi Zuo
Mar 31, 2012·Journal of the American Geriatrics Society·Patrick ImfeldChristoph R Meier
Aug 7, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y IshibashiS Yamagishi
Jan 2, 2013·Trends in Pharmacological Sciences·Arian Emami RiedmaierMatthias Schwab
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Heather A HirschKevin Struhl
Sep 7, 2013·Diabetes Care·Eileen M MooreUNKNOWN AIBL Investigators
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Geert Jan BiesselsRachel A Whitmer
Mar 24, 2015·Diabetes Research and Clinical Practice·José A LuchsingerUNKNOWN Finnish Diabetes Prevention Study (DPS)
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·José A LuchsingerEmilia Bagiella
Citations
Oct 13, 2018·Metabolic Syndrome and Related Disorders·Michael Palacios-MendozaRocio Santibanez
Feb 16, 2019·PloS One·Galit WeinsteinSudha Seshadri
Apr 16, 2019·Obesity·María Arnoriaga RodríguezJosé Manuel Fernández-Real
Aug 5, 2017·Diabetologia·Willy Marcos ValenciaHermes Florez
Dec 4, 2019·The Cochrane Database of Systematic Reviews·Kasper S MadsenBianca Hemmingsen
Nov 2, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Silvia SciannimanicoVincenzo Triggiani
Jan 4, 2020·GeroScience·Kiran ChaudhariShao-Hua Yang
Oct 26, 2018·International Journal of Molecular Sciences·Andrea TumminiaLucia Frittitta
Sep 11, 2020·Archives of Pharmacal Research·Heeyoung Lee, EunYoung Kim
Jan 24, 2020·Brain Plasticity·Patrick J Smith
Mar 27, 2019·Molecular Brain·Chang ShanJian-Min Liu
Mar 29, 2019·The Journal of Clinical Endocrinology and Metabolism·Kirsty M PorterHelene McNulty
Sep 25, 2020·Diabetes Care·Katherine SamarasPerminder S Sachdev
Jul 17, 2020·Computational and Structural Biotechnology Journal·Yue LiuNady Braidy
Dec 29, 2020·Journal of Psychiatric Research·Shen LiXiang Yang Zhang
Feb 10, 2021·Diabetologia·Geert Jan BiesselsOdd Erik Johansen
Nov 24, 2020·Neuropsychiatric Disease and Treatment·Victoria SanbornJohn Gunstad
Feb 21, 2021·Ageing Research Reviews·Benjamin KioussisAndrea B Maier
Mar 23, 2021·Journal of Diabetes and Its Complications·Felicia R SimpsonUNKNOWN Indices for Accelerated Aging in Obesity and Diabetes Ancillary Study of the Action for Health in Diabetes (Look AHEAD) Tria
Jun 3, 2021·Pharmaceuticals·Barbara MiziakStanisław J Czuczwar
Jun 3, 2021·Journal of Clinical Medicine·Diana Maria AritonPilar Delgado
Jul 21, 2021·Current Medical Research and Opinion·Ulrike Hostalek, Ian Campbell
Aug 28, 2021·Cells·Pasquale MoneGaetano Santulli