Metformin maintains the weight loss and metabolic benefits following rimonabant treatment in obese women with polycystic ovary syndrome (PCOS)

Clinical Endocrinology
Thozhukat SathyapalanS L Atkin

Abstract

Rimonabant has been shown to reduce weight, free androgen index (FAI) and insulin resistance in obese patients with polycystic ovary syndrome (PCOS) compared to metformin. Studies have shown that significant weight regain occurs following the cessation of rimonabant therapy. This study was undertaken to determine if subsequent metformin treatment after rimonabant would maintain the improvement in weight, insulin resistance and hyperandrogenaemia in PCOS. An extension study for 3 months with the addition of metformin to the randomised open labelled parallel study of metformin and rimonabant in 20 patients with PCOS with a body mass index >or= 30 kg/m(2). Patients who were on 3 months of rimonabant were changed over to metformin for 3 months, whereas those on 3 months of metformin were continued on metformin for another 3 months. The primary end-point was a change in weight; secondary end-points were a change in FAI and insulin resistance. The mean weight loss of 6.2 kg associated with 3 months of rimonabant treatment was maintained by 3 months of metformin treatment (mean change +0.2 kg, P = 0.96). Therefore, the percentage reduction in weight remained significantly higher in the rimonabant/metformin group compared to metformin ...Continue Reading

References

Mar 1, 1997·Fertility and Sterility·S E AllenR Azziz
Nov 5, 1999·Human Reproduction·E KoustaS Franks
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Richard FlemingNaveed Sattar
Feb 21, 2002·Trends in Endocrinology and Metabolism : TEM·Anders H BergPhilipp E Scherer
Jul 26, 2002·Life Sciences·W M LiuY J Cao
May 17, 2003·Fertility and Sterility·Rebecca MansfieldHelen Mason
Oct 25, 2003·BMJ : British Medical Journal·Jonathan M LordRobert J Norman
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Jan 30, 2004·American Journal of Obstetrics and Gynecology·Michael C DennedyJohn J Morrison
Feb 18, 2004·Fertility and Sterility·Gustavo Arantes Rosa MacielEdmund C Baracat
Nov 24, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y L LiuM J Stock
May 3, 2005·The Journal of Clinical Investigation·Douglas Osei-HyiamanGeorge Kunos
May 12, 2005·The Journal of Clinical Endocrinology and Metabolism·Lyndal R HarborneRichard Fleming
Nov 18, 2005·The New England Journal of Medicine·Jean-Pierre DesprésUNKNOWN Rimonabant in Obesity-Lipids Study Group
Feb 16, 2006·JAMA : the Journal of the American Medical Association·F Xavier Pi-SunyerUNKNOWN RIO-North America Study Group
Mar 1, 2007·Molecular Pharmacology·Maurizio BifulcoAntonietta Santoro

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Citations

Jan 19, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H M ParrettiP Aveyard
Jan 5, 2011·Journal of Obesity·Hassan KahalThozhukat Sathyapalan
Dec 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A J DawsonS L Atkin
Apr 29, 2015·The Cochrane Database of Systematic Reviews·Esther J van ZuurenNikolaos Pandis
Jul 17, 2020·Therapeutic Advances in Endocrinology and Metabolism·Mohammed Altigani AbdallaThozhukat Sathyapalan
Jan 15, 2010·Current Opinion in Obstetrics & Gynecology

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