Metformin one in a Million Efficient Medicines for Rheumatoid Arthritis Complications: Inflammation, Osteoblastogenesis, Cardiovascular Disease, Malignancies

Current Rheumatology Reviews
Elham RajaeiZeinab D Zayeri

Abstract

Rheumatoid arthritis is a widespread autoimmune disease and inflammation and bone destruction are two main issues in rheumatoid arthritis. To discussing metformin effects on rheumatoid arthritis complications. We conducted a narrative literature search including clinical trials, experimental studies on laboratory animals and cell lines. Our search covered Medline, PubMed and Google Scholar databases from 1999 until 2018. We used the terms" Metformin; Rheumatoid arthritis; Cardiovascular disease; Cancer; Osteoblastogenesis. Inflammatory pro-cytokines such as Interlukin-6 play important roles in T. helper 17 cell lineage differentiation. Interlukin-6 and Tumor Necrosis Factor-α activate Janus kinase receptors signal through signaling transducer and activator of transcription signaling pathway which plays important role in inflammation, bone destruction and cancer in rheumatoid arthritis patients. Interlukin-6 and Tumor Necrosis Factor-α synergistically activate signaling transducer and activator of transcription and Nuclear Factor-kβ pathways and both cytokines increase the chance of cancer development in rheumatoid arthritis patients. Metformin is AMPK activators that can suppress mTOR, STAT3 and HIF-1 so AMPK activation plays i...Continue Reading

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Citations

Nov 28, 2018·Journal of Cellular Physiology·Zeinab Deris ZayeriMohammadreza Hajjari
Mar 14, 2019·Journal of Cellular Physiology·Saeid ShahrabiElham Rajaei
Sep 23, 2018·International Journal of Molecular Sciences·Joseph ZhouLixin Li
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Sep 10, 2020·Pharmaceuticals·Teresa SalvatoreFerdinando Carlo Sasso
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Xi JiaQiaohui Qian

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