Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Shokouh AhmadiHariom Yadav

Abstract

Aging-related illnesses are increasing and effective strategies to prevent and/or treat them are lacking. This is because of a poor understanding of therapeutic targets. Low-grade inflammation is often higher in older adults and remains a key risk factor of aging-related morbidities and mortalities. Emerging evidence indicates that abnormal (dysbiotic) gut microbiome and dysfunctional gut permeability (leaky gut) are linked with increased inflammation in older adults. However, currently available drugs do not treat aging-related microbiome dysbiosis and leaky gut, and little is known about the cellular and molecular processes that can be targeted to reduce leaky gut in older adults. Here, we demonstrated that metformin, a safe Food and Drug Administration-approved antidiabetic drug, decreased leaky gut and inflammation in high-fat diet-fed older obese mice, by beneficially modulating the gut microbiota. In addition, metformin increased goblet cell mass and mucin production in the obese older gut, thereby decreasing leaky gut and inflammation. Mechanistically, metformin increased the goblet cell differentiation markers by suppressing Wnt signaling. Our results suggest that metformin can be used as a regimen to prevent and treat ...Continue Reading

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Citations

May 18, 2020·International Journal of Molecular Sciences·Ravinder NagpalHariom Yadav
Jun 20, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Thomas W Buford
Nov 1, 2020·The Journal of Clinical Endocrinology and Metabolism·Sidharth P MishraHariom Yadav
Feb 11, 2021·International Journal of Molecular Sciences·Brandi MillerHariom Yadav
Dec 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Qi Zhang, Nan Hu
Mar 5, 2021·Risk Management and Healthcare Policy·Bocong YuanGuojun Zeng
Apr 4, 2021·International Journal of Molecular Sciences·Chae Bin LeeSoo Kyung Bae
Apr 6, 2021·Aging and Disease·Die HuTianyu Zhong
Jul 11, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S Carter
Aug 13, 2021·Neural Regeneration Research·Leelavathi N MadhuAshok K Shetty

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