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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

Cell Stem Cell

Oct 3, 2019

Björn NeumannRobin J M Franklin

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Abstract

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. He...read more

Mentioned in this Paper

Cell Aging
Cell Differentiation Process
Chronic Disease
Demyelination
Differential Diagnosis
DNA Damage
Metformin
Multiple Sclerosis
Nerve Degeneration
Oligodendroglia
184
99
5
49
2
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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

Cell Stem Cell

Oct 3, 2019

Björn NeumannRobin J M Franklin

PMID: 31585093

DOI: 10.1016/j.stem.2019.08.015

Abstract

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. He...read more

Mentioned in this Paper

Cell Aging
Cell Differentiation Process
Chronic Disease
Demyelination
Differential Diagnosis
184
99
5
49
2

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