Metformin therapy and cognitive dysfunction in patients with type 2 diabetes: A meta-analysis and systematic review.

Medicine
Qing-Qing ZhangRui-Xia Zhang

Abstract

Type 2 diabetes (T2D) is a risk factor for cognitive dysfunction. The relationship between metformin therapy and cognitive function in patients with T2D is unknown. Therefore, we determined the relationship between metformin therapy and cognitive function in patients with T2D using a meta-analysis. We systematically searched the Cochrane library, PubMed, and Embase to identify studies showing correlations, and we calculated hazard ratios (HRs). We identified 10 studies including 254,679 participants. Metformin significantly reduced the occurrence of cognitive dysfunction in patients with T2D (HR 0.90; 95% CI [0.88, 0.92]). Compared with other hypoglycemic drugs, sulfonylureas also improved cognitive dysfunction (HR 0.92; 95% CI [0.88, 0.95]). Thiazolidinediones gave no statistically significant improvement in cognitive dysfunction (HR 0.97; 95% CI [0.87, 1.07]). The use of insulin aggravated cognitive dysfunction (HR 1.34; 95% CI [1.24, 1.43]). In the subgroup analysis of various regions controlling for age, gender, education, diabetes course, complications, metformin administration and dosage, and follow-up time, metformin significantly improved cognitive dysfunction in patients in the Americas and Europe (HR 0.69; 95% CI [0.6...Continue Reading

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Citations

Sep 16, 2020·Biotechnology and Applied Biochemistry·Yan-Fen LeeLay-Harn Gam
Feb 21, 2021·Diabetes Care·Andrea GiaccariStefano Del Prato
Jun 25, 2021·Frontiers in Neuroscience·Kevin K K YuAlex Kwok-Kuen Cheung
Jul 3, 2021·Nutrients·Milagros RojasEdgar Díaz-Camargo

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