Metformin therapy and postoperative atrial fibrillation in diabetic patients after cardiac surgery

Journal of Intensive Care
Suresh BasnetRenee Pekmezaris

Abstract

Postoperative atrial fibrillation (AF) commonly occurs in cardiac surgery patients. Studies suggest inflammation and oxidative stress contribute to postoperative AF development in this patient population. Metformin exerts an anti-inflammatory effect that reduces oxidative stress and thus may play a role in preventing postoperative AF. We conducted a matched, retrospective cohort study of diabetic patients' age ≥18 undergoing a coronary artery bypass graft (CABG) and/or cardiac valve surgery from January 1, 2009, to November 30, 2014. We extracted data from The Society of Thoracic Surgeons National Adult Cardiac Surgery Database. Primary exposure was ongoing metformin use at a dose of ≥ 500 mg in effect before cardiac surgery as captured before admission. Primary study outcome was postoperative AF incidence. Matching was used to reduce selection bias between metformin and non-metformin groups. Comparison between the groups after matching was accomplished using the McNemar test or paired t test. Out of the 4177 patients with cardiac surgery (CABG and/or valve surgery), 1283 patients met our study criteria. These patients were grouped into metformin [n = 635 (49.5%)] and non-metformin [n = 648 (50.5%)] users. Pre-matching, postope...Continue Reading

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Citations

Sep 18, 2020·Journal of Cardiac Surgery·Marco Shiu Tsun LeungAmer Harky
Nov 26, 2020·Cardiovascular Diabetology·Teerapat NantsupawatNipon Chattipakorn
Nov 24, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Parker O'NeillAmer Harky

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

Clinical Intelligence System
SAS

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