Metformin therapy before conception versus throughout the pregnancy and risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systemic review, meta-analysis and meta-regression

Diabetology & Metabolic Syndrome
Razieh Bidhendi YarandiFahimeh Ramezani Tehrani

Abstract

The results of studies that assessed the impact of metformin treatments on gestational diabetes mellitus (GDM) in patients with polycystic ovary syndrome (PCOS) are inconclusive. In addition, the impact of time and duration of metformin therapy for an optimum reduction of GDM has not been reported in these studies. This study aimed to summarize current knowledge regarding the effect of metformin-therapy before conception versus throughout pregnancy on the risk of GDM in women with PCOS. PubMed, Scopus, Google Scholar and ScienceDirect databases were searched to identify relevant studies. Both fixed and random effect models were used. Subgroup analyses were performed based on the on the study methodology. The association between the PCOS status and GDM was assessed using the univariate and multiple meta-regression analysis adjusted by the BMI and metformin therapy. Forty-eight of 1397 identified studies were included involving 5711 PCOS patients and 20,296 controls. Regardless of metformin therapy, the prevalence of GDM diagnosed in the second trimester among women with PCOS was significantly higher than healthy controls that was independent of obesity. Including all studies, the increased risk of GDM among women with PCOS, comp...Continue Reading

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Citations

Nov 2, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Suhail A R DoiLukman Thalib
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Jul 21, 2021·Current Medical Research and Opinion·Ulrike Hostalek, Ian Campbell
Oct 5, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·K K VenkateshM B Landon

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