Metformin treatment does not affect the risk of ruptured abdominal aortic aneurysms

Journal of Vascular Surgery
Katrine L KristensenJes S Lindholt

Abstract

Diabetes counteracts formation and rupture of abdominal aortic aneurysms, possibly through arterial matrix accumulation. Use of metformin, on the other hand, reduces arterial accumulation of matrix molecules. Consequently, we hypothesized that metformin treatment may reverse the protective role of diabetes on the development and course of aneurysms, that is, that metformin would be associated with aneurysm rupture among individuals with diabetes. Using nationwide Danish registry data, we performed a nested case-control study on the association between long-term use of metformin and ruptured abdominal aortic aneurysm (RAAA). The source population was defined as all individuals in Denmark with diabetes. Cases were all individuals within the source population who were hospitalized with a primary diagnosis of RAAA. For each case, 10 controls matched by age and sex were randomly selected from the source population by risk set sampling. The main exposure measure was a cumulative dispensing of 1000 g of metformin between January 1995 and the index date. We identified 362 cases of RAAA during 1998 to 2013, of which 83.7% occurred in men with a median age of 74 years. In total, 22.4% of the case population were long-term metformin users...Continue Reading

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Citations

Jun 8, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Nikesh DattaniMatthew J Bown
Jul 28, 2018·Cardiovascular Research·Juliette RaffortZiad Mallat
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May 16, 2021·Journal of Cardiovascular Pharmacology·Bitao XiangKai Zhu
Nov 16, 2019·Journal of Vascular Surgery·Juliette RaffortFabien Lareyre
Oct 26, 2021·Journal of Vascular Surgery·Matthew J NordnessJohn A Curci

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