Abstract
Preclinical evidence suggests that metformin could delay cancer progression. Previous epidemiological studies however have been limited by small sample sizes and certain time-related biases. This study aimed to investigate whether colorectal cancer patients with type 2 diabetes who were exposed to metformin had reduced cancer-specific mortality. We conducted a retrospective cohort study of 1,197 colorectal cancer patients newly diagnosed from 1998 to 2009 (identified from English cancer registries) with type 2 diabetes (based upon Clinical Practice Research Datalink, CPRD, prescription and diagnosis records). In this cohort 382 colorectal cancer-specific deaths occurred up to 2012 from the Office of National Statistics (ONS) mortality data. Metformin use was identified from CPRD prescription records. Using time-dependent Cox regression models, unadjusted and adjusted hazard ratios (HR) and 95% CIs were calculated for the association between post-diagnostic exposure to metformin and colorectal cancer-specific mortality. Overall, there was no evidence of an association between metformin use and cancer-specific death before or after adjustment for potential confounders (adjusted HR 1.06, 95% CI 0.80, 1.40). In addition, after adju...Continue Reading
References
Mar 30, 1991·BMJ : British Medical Journal·H JickL E Derby
Jun 1, 2004·Sexually Transmitted Infections·H NobleY H Carter
Jul 20, 2007·Cancer Research·Monica BuzzaiCraig B Thompson
Jan 14, 2009·Cancer Prevention Research·Mahvash ZakikhaniMichael N Pollak
May 20, 2009·Statistics in Medicine·Ian R White, Patrick Royston
Jul 1, 2009·BMJ : British Medical Journal·Jonathan A C SterneJames R Carpenter
Jan 7, 2010·BMC Family Practice·Nada F KhanPeter W Rose
Feb 10, 2010·International Journal of Epidemiology·Diana SarfatiNeil Pearce
Mar 17, 2010·Endocrine-related Cancer·Carolyn AlgireMichael Pollak
Mar 17, 2010·BMJ : British Medical Journal·Linda E LévesqueSamy Suissa
Dec 31, 2010·The Journal of Clinical Endocrinology and Metabolism·Bee K TanHarpal S Randeva
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jin Ha LeeWon Ho Kim
Mar 17, 2012·British Journal of Cancer·C R GarrettM M Hassan
Nov 23, 2012·Diabetes Care·Samy Suissa, Laurent Azoulay
Dec 15, 2012·Pharmacoepidemiology and Drug Safety·Rachael BoggonMike A Richards
Jan 10, 2013·PloS One·H T KwanHextan Y S Ngan
Jun 19, 2013·Cancer Epidemiology·Furha Iram CossorJessica K Paulus
Oct 10, 2013·Diseases of the Colon and Rectum·Katherine T MillsGiuseppe Gagliardi
May 27, 2014·PloS One·Eveline A I F QueirozNeelam Khaper
Citations
Oct 22, 2016·Frontiers in Oncology·Valentina RosatoCristina Bosetti
Dec 17, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rashmi R Shah
Jan 27, 2016·Journal of Pharmacy Practice·George K NimakoAlice C Ceacareanu
Feb 7, 2017·Epidemiology·Samy Suissa
Dec 23, 2017·Biological Chemistry·Stephen SafeKeshav Karki
Feb 13, 2018·International Journal of Cancer. Journal International Du Cancer·Tina FransgaardIsmail Gögenur
Jan 19, 2018·Scientific Reports·Da-Zhi ChenLan-Juan Li
Dec 14, 2019·Journal of Experimental & Clinical Cancer Research : CR·Muhamad Noor Alfarizal KamarudinIshwar Parhar
Feb 27, 2020·International Journal of Colorectal Disease·Yunzi WangJiang Du
Jan 20, 2017·Oncotarget·Lili DuChanglong Bi
Oct 1, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Audrius DulskasGiedre Smailyte
Jun 28, 2020·International Journal of Colorectal Disease·Cheng-Ann Winston NgChin Meng Khoo
Mar 21, 2020·International Journal of Cancer. Journal International Du Cancer·Wen-Kuan HuangLai-Chu See
Aug 15, 2020·Cancer Science·Akira SaitoNaohiro Sata
May 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jinye XieGuoquan Gao
Aug 28, 2020·BioMed Research International·Jing SangQing Sun
Mar 9, 2017·Journal of Diabetes Research·Fanqiang MengWenyue Wang
Nov 28, 2017·JNCI Cancer Spectrum·Xun CaoXin Wang
Jul 27, 2017·Gastroenterology Research and Practice·Yaodu WangLikuan Hu
Aug 9, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jessica K PaulusRobert E Martell
Dec 11, 2019·Pathology, Research and Practice·Min DengHonghe Zhang
Jan 6, 2021·British Journal of Cancer·Arinilda Campos BragagnoliJoão Paulo da Silveira Nogueira Lima
Apr 10, 2021·Diabetes Research and Clinical Practice·Jia-Li Feng, Xiwen Qin
Apr 30, 2021·World Journal of Gastroenterology : WJG·Maja Cigrovski BerkovicAnna Mrzljak
Oct 22, 2021·Frontiers in Physiology·Varda Shoshan-BarmatzAnna Shteinfer-Kuzmine