Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

Journal of Alzheimer's Disease : JAD
Jared M CampbellEdoardo Aromataris

Abstract

Metformin, a first line antihyperglycemic medication, is an AMPK activator and has been hypothesized to act as a geroprotective agent. Studies on its association with various classifications of age-related cognitive decline have shown mixed results with positive and negative findings. To synthesize the best available evidence on the association of metformin-use with risk, progression, and severity of dementia. Eligible research investigated the effect of metformin on dementia, Alzheimer's disease, or any measure of cognitive impairment compared to any control group who were not receiving metformin. The initial search resulted in 862 citations from which 14 studies (seven cohort, four cross-sectional, two RCTs, and one case control) were included. Meta-analysis of three studies showed that cognitive impairment was significantly less prevalent in diabetic metformin (Odds ratio = 0.55, 95% CI 0.38 to 0.78), while six studies showed that dementia incidence was also significantly reduced (Hazard ratio = 0.76, 95% CI 0.39 to 0.88). Mini-Mental State Examination scores were not significantly affected by metformin-use, although both RCTs showed that metformin had a neuroprotective effect compared to placebo. Some studies found negative...Continue Reading

References

Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Sep 23, 2003·Diabetes & Metabolism·P Beisswenger, D Ruggiero-Lopez
Aug 30, 2005·Experimental Gerontology·Vladimir N AnisimovClaudio Franceschi
Nov 6, 2007·Diabetes·Olov RolandssonLars-Göran Nilsson
Aug 20, 2008·Food and Nutrition Bulletin·Erin McLeanLindsay H Allen
Dec 17, 2008·Toxicologic Pathology·Rozalyn M AndersonRichard Weindruch
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·A V WitteA Flöel
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yaomin ChenFrancesca-Fang Liao
Apr 24, 2010·Journal of Alzheimer's Disease : JAD·José A Luchsinger
Feb 8, 2011·Journal of Alzheimer's Disease : JAD·Chih-Cheng HsuHsin-Ni Tsai
Jan 10, 2012·International Psychogeriatrics·Eileen MooreDavid Watters
Mar 31, 2012·Journal of the American Geriatrics Society·Patrick ImfeldChristoph R Meier
Jun 5, 2012·Diabetes Research and Clinical Practice·Raúl O DomínguezJorge A Serra
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
Sep 7, 2013·Diabetes Care·Eileen M MooreUNKNOWN AIBL Investigators
Mar 1, 2014·Journal of Alzheimer's Disease : JAD·Tze Pin NgBengt Winblad
May 21, 2014·Journal of Diabetes Investigation·Kapil GudalaAnil Bhansali
Jun 6, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chin ChengTsuo-Hung Lan
Mar 15, 2015·Experimental & Molecular Medicine·Bhumsoo Kim, Eva L Feldman
May 15, 2015·Annals of Neurology·Michael T HenekaGabriele Doblhammer
Jul 22, 2015·The Journal of Nutrition, Health & Aging·T K MalmstromJ E Morley
Dec 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Christoph Handschin
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·José A LuchsingerEmilia Bagiella
Apr 8, 2016·Current Medical Research and Opinion·Shengsheng YuLarry Radican
May 20, 2016·BioMed Research International·Pushpani M HerathKaarin J Anstey
Jun 3, 2016·Dementia and Geriatric Cognitive Disorders·Fang YeGang Yi
Jul 16, 2016·Circulation Research·Amy R CameronGraham Rena
Aug 30, 2016·Indian Journal of Psychological Medicine·Deepti KhattarS V Madhu
Oct 27, 2016·Journal of the American Medical Directors Association·Anthony LicciniJohn E Morley
Feb 14, 2017·Journal of Diabetes and Its Complications·Chen-Pin WangSara E Espinoza
Jun 7, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yi-Chun KuanChia-Hung Kao
Aug 12, 2017·JBI Database of Systematic Reviews and Implementation Reports·Jared M CampbellEdoardo Aromataris

❮ Previous
Next ❯

Citations

May 28, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Devin WahlDavid G Le Couteur
Nov 30, 2019·The Journal of Clinical Endocrinology and Metabolism·Janet K SluggettSirpa Hartikainen
Mar 13, 2020·American Journal of Alzheimer's Disease and Other Dementias·Hayato AkimotoDaisuke Kobayashi
Nov 22, 2019·Reviews in the Neurosciences·Bor Luen Tang
Sep 16, 2020·Biotechnology and Applied Biochemistry·Yan-Fen LeeLay-Harn Gam
Jun 27, 2019·Journal of Psychopharmacology·Teodoro Del SerMiguel A Fernández-Blázquez
Jul 28, 2020·Nature Reviews. Drug Discovery·Stephen C CunnaneMark J Millan
Jun 25, 2019·The Journal of Nutrition, Health & Aging·J E Morley
Oct 8, 2019·Current Aging Science·Yadollah A MomtazMaryam Hazrati
Mar 12, 2020·Brain Sciences·Ibrahim AlharbiAhmad Alhowail
Feb 27, 2020·Antioxidants & Redox Signaling·Cristina Carvalho, Susana Cardoso
Jul 1, 2020·Frontiers in Neurology·Carolina SportelliK Ray Chaudhuri
Apr 7, 2020·Journal of Alzheimer's Disease : JAD·Lily LiKerryn E Pike
Jul 18, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zahra SalehiMina Ohadi
Nov 10, 2020·Expert Review of Neurotherapeutics·Sarah DemaréPaul Fernyhough
Nov 5, 2020·Mechanisms of Ageing and Development·Samir Morsli, Ilaria Bellantuono
Mar 2, 2021·Frontiers in Aging Neuroscience·Jose A Santiago, Judith A Potashkin
Jul 11, 2020·European Journal of Pharmacology·Moumita NathYashmin Choudhury
Mar 30, 2021·International Journal of General Medicine·Amy W RachfalStanley S Schwartz
Apr 14, 2021·Ophthalmology and Therapy·Dewi Fathin RomdhoniyyahNicholas A V Beare
Apr 13, 2021·Frontiers in Neuroendocrinology·Carmen M LabandeiraAna I Rodriguez-Perez
Apr 13, 2021·Molecular Metabolism·Joshua L Milstein, Heather A Ferris
Mar 11, 2021·American Journal of Physiology. Cell Physiology·Leena P Bharath, Barbara S Nikolajczyk
Jun 11, 2021·Clinical Therapeutics·Rachel LitkeJudith Neugroschl
Aug 6, 2021·Frontiers in Neuroscience·Zenghui WeiSandra E Reznik
Aug 8, 2021·International Journal of Molecular Sciences·Tien-Wei YuChieh-Hsin Lin
Apr 8, 2020·ACS Pharmacology & Translational Science·Andrew S RichingRushita A Bagchi
Oct 6, 2021·Journal of Neurology·Joseph Pleen, Ryan Townley
Oct 12, 2021·Expert Opinion on Drug Metabolism & Toxicology·Natalie R NeumannVasilis Vasiliou

❮ Previous
Next ❯

Software Mentioned

RevMan Review Manager
ProQuest

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved