Metformin Use During Treatment of Potentially Curable Esophageal Cancer Patients is not Associated with Better Outcomes

Annals of Surgical Oncology
L E A M M SpieringsH W M van Laarhoven

Abstract

Metformin use has been associated with a dose-dependent increased response to neoadjuvant chemo(radio)therapy in esophageal cancer patients. However, no association between metformin use and overall survival has been reported yet. The purpose of our study was to investigate the effect of metformin use on pathological response as well as overall and disease-free survival in patients with resectable esophageal cancer. Between March 1994 and September 2013, all patients undergoing an esophagectomy for esophageal and gastroesophageal junction cancer after neoadjuvant chemo(radio)therapy with curative intent were included in a prospective database. A complete pathological response was defined as ypT0N0M0, Mandard 1. Kaplan-Meier curves with log-rank testing were performed for overall survival and disease-free survival. A total of 461 patients were included with a median follow-up of 24 months (range 1-228); 43 patients were diagnosed with diabetes mellitus type II (9.3 %) of whom 32 patients used metformin (74 %). A total of 94 (20 %) patients had a complete pathological response, which did not differ between metformin users (19 %) and non-metformin users (21 %, p = 0.99). We did not observe a statistically significant difference be...Continue Reading

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Citations

Jan 27, 2016·Journal of Pharmacy Practice·George K NimakoAlice C Ceacareanu
Jan 17, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Xi ZhengRui Jiang
Jun 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Benjamin ChevalierAlexandre Escande
Dec 4, 2019·The Journal of Surgical Research·Taryn E HassingerShayna L Showalter

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