Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat.

Journal of Pediatric Endocrinology & Metabolism : JPEM
Nelly MaurasPrabhakaran Balagopal

Abstract

To determine if metformin improves markers of inflammation, thrombosis, and intrahepatic fat contents in children with uncomplicated obesity. Obese children with normal glucose tolerance but elevated highly sensitive C-reactive protein (hsCRP) and/or fibrinogen concentrations (>2 standard deviations) were randomized to structured diet/exercise or diet/exercise and metformin for 6 months. Blood samples, dual energy X-ray absorptiometry data, and liver magnetic resonance images were obtained. Forty-two of 66 recruited children (7-18 years) completed 6 months. Weight loss was modest but more pronounced in the metformin group (-4.9 +/- 1.0 kg) than in the diet/exercise group (-1.7 +/- 1.1 kg, p<0.03), whereas hsCRP and fibrinogen decreased more in the diet/exercise pubertal group. Baseline intrahepatic fat was high but decreased only in the diet/exercise (not metformin) pubertal group. Six months of metformin therapy improved weight loss and reduced abdominal adiposity, but did not enhance the beneficial effect of diet and exercise on markers related to inflammation, thrombosis, or hepatic fat in obese children with normal glucose tolerance.

Citations

Aug 21, 2013·Paediatric Drugs·Deborah L KendallPeter E Clayton
Jul 24, 2012·The Journal of Pediatrics·Matthew BensonNelly Mauras
Aug 3, 2014·Experimental Physiology·S AstizI Garcia-Real
Jul 16, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C MoserJ Drewe
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Nov 5, 2014·The Annals of Pharmacotherapy·Cassie L BolandKira B Harris
Nov 30, 2016·The Cochrane Database of Systematic Reviews·Emma MeadLouisa J Ells
Aug 3, 2018·Childhood Obesity·Loretta S WarnakulasuriyaV Pujitha Wickramasinghe
Apr 10, 2015·The Journal of Clinical Endocrinology and Metabolism·Nelly MaurasIan A Blair
Mar 31, 2017·The Journal of Clinical Endocrinology and Metabolism·Tamim RajjoMohammad Hassan Murad
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