Metformin use in diabetics with diverticular disease is associated with reduced incidence of diverticulitis

Scandinavian Journal of Gastroenterology
Julia FreckeltonGregory Thomas Moore

Abstract

There is no current, evidence-based therapy to prevent acute diverticulitis in patients with diverticular disease. Metformin has been shown to have anti-inflammatory effects in a number of disease states, in both animal models and in human observational studies. The potential therapeutic efficacy of metformin in diverticular disease has not been investigated. This study aims to describe the relationship between metformin use and diverticular disease in patients with diabetes mellitus. This was a retrospective case-control study. It compared metformin and other hypoglycaemic medication use in diabetic patients with uncomplicated diverticulosis to those with acute diverticulitis. Patients were identified using hospital International Classification of Diseases 10 (ICD-10) data, and radiology, pathology and scanned medical record databases were used to confirm diagnoses and collect all information. Chi square tests were used to determine significance of difference in categorical variables, and Mann-Whitney tests were used for continuous data. There were 174 patients with uncomplicated diverticulosis and 175 patients with acute diverticulitis. A diagnosis of acute diverticulitis was associated with a significantly lower incidence of...Continue Reading

References

Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A TursiR Daffinà
Oct 22, 2008·Journal of Clinical Gastroenterology·Jerry MartelUNKNOWN NDSG
Nov 11, 2008·Gastroenterology·Lisa L StrateEdward L Giovannucci
Feb 13, 2009·Annals of Surgery·David A EtzioniAndreas M Kaiser
Aug 19, 2011·American Journal of Physiology. Renal Physiology·Patricia W Seo-MayerMichael J Caplan
Sep 20, 2011·International Journal of Colorectal Disease·Bastiaan R KlarenbeekMiguel A Cuesta
Apr 10, 2014·Journal of Gastroenterology and Hepatology·Seong-Joon KohJoo Sung Kim
Jul 20, 2014·Gastroenterology·Jeffrey B RaskinPaul Streck
Dec 24, 2014·JAMA : the Journal of the American Medical Association·Silvio E InzucchiDarren K McGuire
Sep 30, 2015·The American Journal of Gastroenterology·Adil E BharuchaAlan R Zinsmeister
Apr 30, 2016·The American Journal of Gastroenterology·Muhammad Ali KhanColin W Howden
Jul 16, 2016·Circulation Research·Amy R CameronGraham Rena
Sep 14, 2016·International Journal of Pediatric Otorhinolaryngology·Jae Gu ChoSung Won Chae

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.