Metformin versus acarbose therapy in patients with polycystic ovary syndrome (PCOS): a prospective randomised double-blind study

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Aida Hanjalic-BeckDominik Denschlag

Abstract

The objective of this study was to investigate the effect of metformin versus acarbose in terms of ovulation rate, their impact on hormonal and metabolic status and tolerability of both drugs in patients with polycystic ovary syndrome (PCOS). Seventy-five patients with PCOS were included in this prospective randomised controlled double-blinded clinical study. According to randomisation, patients were allocated to receive either metformin 2550 mg/day (n = 37) or acarbose 300 mg/day (n = 38) for 12 weeks. Primary study outcomes were ovulation rate, restoration of a regular menstrual cycle and the incidence of side effects. Secondary outcomes included treatment-related hormonal and metabolic changes. Comparable high rates of regular menstrual cycles as well as ovulation could be achieved in both groups (70% and 73% for metformin vs. 78% and 59% for acarbose, p = 0.330 and p = 0.185, respectively). In contrast, only in patients treated with metformin a statistically significant decrease in fasting insulin and cholesterol levels as well as BMI was observed. However, comparing both groups at the end of treatment, no significant differences in metabolic and/or hormonal parameters could be detected. Regarding side effects, the rate of ...Continue Reading

References

Sep 28, 1995·The New England Journal of Medicine·S Franks
Jul 1, 1997·Human Reproduction Update·E KoustaS Franks
Jun 25, 1998·The New England Journal of Medicine·J E NestlerR Pasquali
Aug 24, 1999·Annals of Internal Medicine·R A DeFronzo
Dec 20, 2000·American Journal of Obstetrics and Gynecology·R L Barbieri
Jun 28, 2002·Lancet·Jean-Louis ChiassonUNKNOWN STOP-NIDDM Trail Research Group
Sep 10, 2002·Obstetrical & Gynecological Survey·Elizabeth Anna Pritts
Apr 12, 2003·Obstetrics and Gynecology·Robert L Barbieri
May 17, 2003·Fertility and Sterility·Ricardo AzzizUNKNOWN PCOS/Troglitazone Study Group
Oct 7, 2004·American Journal of Obstetrics and Gynecology·R Jeffrey Chang
Sep 28, 2005·Treatments in Endocrinology·Laurel Stadtmauer, Sergio Oehninger
Dec 15, 2005·The Journal of Clinical Endocrinology and Metabolism·S EisenhardtT Strowitzki
Feb 9, 2007·The New England Journal of Medicine·Richard S LegroUNKNOWN Cooperative Multicenter Reproductive Medicine Network

❮ Previous
Next ❯

Citations

Apr 13, 2011·Journal of Assisted Reproduction and Genetics·Sedigheh GhandiMohammad Hossein Sojoodi Moghaddam
Oct 22, 2015·Expert Opinion on Therapeutic Targets·Shruthi Mahalingaiah, Evanthia Diamanti-Kandarakis
Dec 21, 2011·Steroids·Antoni J Duleba
Mar 10, 2017·Expert Review of Clinical Pharmacology·Elizabeth Mary LamosStephen N Davis
Mar 26, 2021·The Cochrane Database of Systematic Reviews·Seyed Abdolvahab TaghaviFatemeh Bazarganipour
Nov 18, 2018·Metabolism: Clinical and Experimental·Charles J Glueck, Naila Goldenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.