Metformin with everolimus and octreotide in pancreatic neuroendocrine tumor patients with diabetes

Future Oncology
Sara PuscedduFilippo de Braud

Abstract

A bidirectional relationship seems to exist between diabetes mellitus and development of pancreatic tumors. Metformin, the most widely used drug in the treatment of Type 2 diabetes mellitus, has recently emerged as a potentially active agent in cancer chemoprevention and treatment. In this article, we discuss the potential correlation between glycemic status, administration of antiglycemic treatments, such as metformin or insulin, and prognosis of pancreatic neuroendocrine tumors patients treated with everolimus and octreotide, on the basis of existing evidence and our experience.

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Citations

Sep 29, 2018·The Journal of Clinical Endocrinology and Metabolism·Aura D Herrera-MartínezRaúl M Luque
Mar 28, 2017·Therapeutic Advances in Medical Oncology·Sara PuscedduGiuseppe Procopio
Jun 16, 2017·Investigational New Drugs·Remco J MolenaarJohanna W Wilmink

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Clinical Trials Mentioned

NCT02294006
NCT02279758

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