PMID: 3543095Jan 1, 1987

Methacholine responsiveness increases after ultrasonically nebulized water but not after ultrasonically nebulized hypertonic saline in patients with asthma

The Journal of Allergy and Clinical Immunology
C M SmithJ L Black

Abstract

Airway obstruction can be induced in patients with asthma by the inhalation of ultrasonically nebulized aerosols of nonisotonic solutions. It is the change in osmolarity of the periciliary fluid that is believed to be the stimulus for bronchoconstriction. However, it is not known whether hyperosmolar and hypo-osmolar aerosols induce asthma via the same mechanism. We have previously reported that patients with asthma have a reduction in the dose of provoking agent that induces a 20% fall in FEV1 (PD20) for methacholine after challenge with nebulized water. To determine whether hyperosmolar aerosols also increase sensitivity to methacholine, we studied 13 subjects with asthma on 3 days. On day 1, the PD20 to methacholine was determined. On day 2, a challenge with nebulized 4.5% saline was followed by a challenge with methacholine 40 to 60 minutes later. On day 3, a challenge with nebulized water was followed by a methacholine challenge. Sensitivity to methacholine was significantly increased after water (p less than 0.02) but not after 4.5% saline. Furthermore, there was no relationship between the PD20 to water and to 4.5% saline. When the Spearman's correlation coefficient was used to compare sensitivity to the challenges, ther...Continue Reading

References

Sep 1, 1987·Respiration Physiology·M J FinneyJ L Black
Feb 3, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Lisa M YoungMargaret L Wilsher
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·H H Wong, J V Fahy
Mar 1, 1991·The American Review of Respiratory Disease·Sandra D Anderson, C M Smith
Aug 1, 1991·The American Review of Respiratory Disease·A N FreedC E Stream
Feb 26, 2016·European Clinical Respiratory Journal·Sandra D Anderson
Sep 16, 2003·Medicine and Science in Sports and Exercise·Ignazio CirilloEmanuele Crimi
May 8, 1999·Journal of Applied Physiology·Hiroyuki MochizukiAkihiro Morikawa
Dec 18, 2001·Journal of Applied Physiology·Hiroyuki MochizukiAkihiro Morikawa
Nov 25, 2000·Journal of Applied Physiology·R Suzuki, A N Freed

Related Concepts

Osmolarity Measurement
Bronchial Provocation Tests
Bronchoconstriction
Vaporizers
Hypoalphalipoproteinemias
Teens
Asthma
Ultrasonics (Sound)
Methacholine
Saline Solution, Hypertonic

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