PMID: 10924887Aug 5, 2000Paper

Methadone: a review of its pharmacokinetic/pharmacodynamic properties

Journal of Pharmacological and Toxicological Methods
M J Garrido, Iñaki F Trocóniz


During the past decades the use of methadone has been increased as a result of the interest of optimizing its therapeutics in opioid addicts, one of the groups with higher risk for AIDS infection. However standard dose of methadone are far from being the appropriate for relief pain or prevent withdrawal signs in maintenance programs in many patients. To achieve an optimal dose regimen for an individual, the knowledge of the relationship between the pharmacokinetics/pharmacodynamics (pk/pd) drug properties and the demographic and physiopathological characteristics of the subject is required. Unfortunately, there is a lack of studies dealing with the population pk/pd properties of methadone. In the current study, a review of the pk/pd properties of methadone is presented with the aim of understanding the sources of variability in response. This will help in the design of prospective pk/pd studies; in particular, individual data including sex, weight, alpha(1)-acid glycoprotein levels in plasma, concomitant medications, time after starting treatment with methadone and previous exposure to other opioids should be requested. In addition, designs for drug administration should allow the characterization of the plasma-versus-biophase ...Continue Reading


Mar 1, 1975·Clinical Pharmacology and Therapeutics·E AnggårdH R Sullivan
May 1, 1990·Clinical Pharmacology and Therapeutics·C E InturrisiK M Foley
Apr 1, 1986·European Journal of Drug Metabolism and Pharmacokinetics·F P Abramson, M P Lutz
Apr 1, 1987·Clinical Pharmacology and Therapeutics·C E InturrisiK M Foley
Aug 1, 1985·Journal of Pharmacokinetics and Biopharmaceutics·J L GabrielssonL K Paalzow
May 1, 1973·Clinical Pharmacology and Therapeutics·G D Olsen
Jan 1, 1982·European Journal of Clinical Pharmacology·M I NilssonE Anggård
Feb 1, 1981·Clinical Pharmacology and Therapeutics·M K RomachE M Sellers
Jan 1, 1994·Chirality·N SchmidtG Geisslinger
Jan 1, 1993·European Journal of Clinical Pharmacology·K WolffR Calvert
Dec 1, 1995·Journal of Pharmacokinetics and Biopharmaceutics·D M Ouellet, G M Pollack
Mar 1, 1996·The Journal of Pharmacy and Pharmacology·M J GarridoR Calvo
Jun 1, 1996·Therapeutic Drug Monitoring·K KristensenP Sjøgren
Nov 1, 1996·Journal of Pharmacological and Toxicological Methods·T L PierceC Raper
Jan 10, 1997·The Journal of Biological Chemistry·A D BlakeT Reisine
Feb 1, 1997·Therapeutic Drug Monitoring·J N WilkinsW Ling
Jan 29, 1997·European Journal of Pharmacology·K W ChanB C Yoburn
May 8, 1999·British Journal of Clinical Pharmacology·D J FosterF Bochner
Jun 26, 1999·British Journal of Clinical Pharmacology·A Rostami-HodjeganG T Tucker
Feb 10, 2000·International Journal of Clinical Pharmacology and Therapeutics·M J GarridoR Calvo
Aug 23, 1965·JAMA : the Journal of the American Medical Association·V P DOLE, M NYSWANDER

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