Methadone enhances human influenza A virus replication

Addiction Biology
Yun-Hsiang ChenYun Wang

Abstract

Growing evidence has indicated that opioids enhance replication of human immunodeficiency virus and hepatitis C virus in target cells. However, it is unknown whether opioids can enhance replication of other clinically important viral pathogens. In this study, the interaction of opioid agonists and human influenza A/WSN/33 (H1N1) virus was examined in human lung epithelial A549 cells. Cells were exposed to morphine, methadone or buprenorphine followed by human H1N1 viral infection. Exposure to methadone differentially enhanced viral propagation, consistent with an increase in virus adsorption, susceptibility to virus infection and viral protein synthesis. In contrast, morphine or buprenorphine did not alter H1N1 replication. Because A549 cells do not express opioid receptors, methadone-enhanced H1N1 replication in human lung cells may not be mediated through these receptors. The interaction of methadone and H1N1 virus was also examined in adult mice. Treatment with methadone significantly increased H1N1 viral replication in lungs. Our data suggest that use of methadone facilitates influenza A viral infection in lungs and might raise concerns regarding the possible consequence of an increased risk of serious influenza A virus inf...Continue Reading

References

Mar 1, 1989·The Journal of Infectious Diseases·P K PetersonB Sharp
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·V P Dole, M J Kreek
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·M A Horisberger
May 1, 1995·The International Journal of the Addictions·J R Caplehorn, M W Ross
Oct 1, 1993·Neurochemical Research·R E Adams, G F Wooten
Mar 1, 1997·Clinical and Diagnostic Laboratory Immunology·M P NairK C Chadha
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·C Gavériaux-RuffB L Kieffer
Oct 31, 1998·Brain Research. Molecular Brain Research·S RoyH H Loh
Sep 29, 2001·Journal of Applied Microbiology·C W Potter
Jan 5, 2002·The Journal of Infectious Diseases·Yuan LiWen-Zhe Ho
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 12, 2002·Vaccine·M E KitlerD Lavanchy
Nov 12, 2002·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Chang-Jiang GuoWen-Zhe Ho
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark K GreenwaldJon-Kar Zubieta
Sep 8, 2004·International Immunopharmacology·Mark R Hutchinson, Andrew A Somogyi
Sep 10, 2004·American Journal of Therapeutics·Ricardo VallejoRamsun Benyamin
Oct 27, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna FerrariEmilio Sternieri
Mar 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ilona JaspersMichael C Madden
Jul 20, 2005·Drug and Alcohol Dependence·Richard HallinanJohn Attia
Nov 22, 2005·International Journal of Pediatric Otorhinolaryngology·Aydan IkinciogullariEmel Babacan
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sabita RoyJosephine Martin
Dec 20, 2007·The Journal of General Virology·Richard E Randall, Stephen Goodbourn
Feb 2, 2008·Biological & Pharmaceutical Bulletin·Daisei MiyamotoYasuo Suzuki
Mar 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·David JacksonRobert A Lamb
May 30, 2009·Toxicology Letters·Maria José PolancoCarmen González-Martín
Nov 21, 2009·Clinical Psychology Review·Jennifer C VeilleuxAdrienne J Heinz
Aug 10, 2010·Biochimica Et Biophysica Acta·Sergio Perez-AlvarezJoaquin Jordán
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·X PonsodaJ V Castell
Jul 15, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xu WangWen-Zhe Ho
Jun 9, 2012·Substance Use & Misuse·Anna PecoraroGeorge E Woody
Jul 20, 2012·The Journal of Supportive Oncology·Mellar P Davis

❮ Previous
Next ❯

Citations

Apr 14, 2016·Lung·Rudra Bhowmick, Heather Gappa-Fahlenkamp
Jul 26, 2016·Frontiers in Microbiology·Alireza TahamtanVahid Salimi
Dec 6, 2019·Peptides·Richard J Bodnar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.