Methadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study

Scientific Reports
Wei LiYijun Liu

Abstract

Methadone maintenance treatment (MMT) can induce impairments in brain function and structure, despite its clinical effectiveness. However, the effect of chronic MMT on brain white matter (WM) is not fully known. Thirty-three MMT patients underwent diffusion tensor imaging (DTI) twice - at the start of the study (Scan1) and one year later (Scan2). Tract-based spatial statistics were used to investigate changes in fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD) between the two scans. The correlations between DTI indices and methadone consumption and neuropsychological status were analysed. We found significantly decreased FA, decreased AD and increased RD in Scan2 in extensive WM regions; overlapping regions were found in the left posterior limb and the retrolenticular part of internal capsule, superior and posterior corona radiata, bilateral external capsule and the right superior longitudinal fasciculus. In addition, the change of FA in the overlapping regions was positively correlated with the accumulated dosage of methadone use, the RD value in Scan2 and non-planning impulsiveness (NPI) measured at follow-up. The results suggest that methadone has damaging effects on WM integrity. The dose-depen...Continue Reading

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Citations

Nov 4, 2016·The American Journal of Drug and Alcohol Abuse·Scott C WollmanJoaquim Radua
Mar 18, 2017·Reviews in the Neurosciences·Raul Felipe Palma-ÁlvarezCarlos Roncero
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Mar 23, 2021·Current Addiction Reports·Mina M RizkBarbara Stanley

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Software Mentioned

Tract - Based Spatial Statistics ( TBSS )
FMRIB Software Library ( FSL )
FMRIB Software Library FSL
Statistical Package for the Social Sciences
Diffusion Toolbox ( FDT )
DTIFIT
Randomise
FSL
Brain Extraction Tool ( BET )

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