PMID: 6538254Feb 13, 1984Paper

Methadone induced physical dependence in the rat

Life Sciences
G S LingC E Inturrisi

Abstract

Although the morphine withdrawal syndrome has been well described in the rat, a syndrome having similar characteristics has not been demonstrated following chronic methadone treatment. In this study we describe the behavioral effects produced by naloxone (4 mg/kg sc) following 72 hours of continuous iv infusion of methadone, (12.2 micrograms/kg/min), morphine (12.2 to 97.9 micrograms/kg/min) or saline. The cessation of methadone or morphine but not saline treatment followed by naloxone resulted in graded signs including wet dog shakes, escape attempts, self-stimulation and body weight loss and quantal signs including diarrhea, ear blanching, exophthalmos, ptosis, tachypnea and teeth chattering. These results indicate that this mode of methadone administration produces physical dependence characterized by a morphine-like withdrawal syndrome in the rat.

References

Apr 15, 1976·Psychopharmacologia·M D Stanes, C P Brown
Jun 19, 1975·Psychopharmacologia·J A VajdaT P Oei
Jan 1, 1974·Pharmacology·L GrumbachJ E Boston

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Citations

Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·L RönnbäckA Wronski
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·M E Bronson, S B Sparber
May 1, 1992·Pharmacology, Biochemistry, and Behavior·T L PierceJ E Olley
Aug 1, 1998·European Journal of Pharmacology·A ChangG W Pasternak
Jan 23, 2004·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Zhixian MoMing Li
Aug 1, 2015·Behavioural Neurology·Karla Salgado-PugaFernando Peña-Ortega
Oct 26, 1984·Science·G S LingG W Pasternak

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