Methadone maintenance treatment among patients exposed to illicit fentanyl in Rhode Island: Safety, dose, retention, and relapse at 6 months

Drug and Alcohol Dependence
Andrew C StoneTraci C Green

Abstract

Illicitly manufactured fentanyl (IMF) is a potent synthetic opioid that has been contributing to overdose deaths in the United States. This study examined intake toxicology and six-month treatment outcomes for patients newly admitted to a single methadone maintenance treatment program (MMTP) in Rhode Island with a high prevalence of illicit fentanyl. We conducted a retrospective chart review of patients admitted to a single MMTP between November 1st, 2016 and August 31st, 2017 followed for six months. Outcomes measured included: 1) retention in treatment at 6 months; 2) evidence of sustained abstinence; 3) relapse; 4) methadone dosage required to achieve sustained abstinence; and 5) the number of days required to achieve abstinence. We observed 154 unique intake events (representing 147 patients). 80% (n = 123) tested positive for fentanyl at intake. During the six-month follow up period, 32% (n = 49) left treatment before six months, two individuals died within five weeks of discontinuation. No deaths were seen among those remaining in treatment. The majority (89%) who remained in treatment at six months achieved abstinence. No significant difference was seen for dose or time to achieve abstinence. Relapse was common (57%). Re...Continue Reading

Citations

Jan 10, 2020·Drug and Alcohol Review·Shalini Arunogiri, Suzanne Nielsen
Feb 23, 2020·Military Medicine·Zygmunt F DembekAiguo Wu
Mar 27, 2021·Substance Use & Misuse·Divya K ChandraRoman Shrestha
Nov 21, 2020·Journal of Medicinal Chemistry·Christine RobinsonMarco Pravetoni
Aug 14, 2020·ACS Chemical Neuroscience·Anna E RinguetteAaron M Bender

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