Methadone restores local and remote EEG functional connectivity in opioid-dependent patients

The International Journal of Neuroscience
Andrew A FingelkurtsS Kähkönen

Abstract

Currently it has been proposed that normal brain function is critically dependent upon a dynamical balance between functions of local neuronal assemblies and global integrative processes. A loss of such metastable balance in favor of either independent or hyper-ordered processing is considered as the reflection of a brain disease. It has been shown that opioid dependence can be characterized as a disease of brain metastable balance, wherein local functional connectivity (synchronicity within neuronal assemblies) increased and remote functional connectivity (synchronicity between neuronal assemblies) decreased. Since methadone may be used as a maintenance treatment for opioid-dependent patients, the aim of this research was to study how methadone would influence the temporal and metastable cortical organization through the measures of local and remote electroencephalogram (EEG) functional connectivity in six opioid-depended patients who manage to complete at least six-month methadone treatment. The present study demonstrated that average parameters of temporal and metastable organization of the cortical dynamics (indexed by local and remote EEG functional connectivity) in such opioid-dependent patients did not differ from normal...Continue Reading

References

Feb 1, 1975·Archives of General Psychiatry·E R GritzJ Schlesinger
Jan 1, 1988·Brain Topography·P Rappelsberger, H Petsche
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G TononiG M Edelman
Feb 1, 1997·NeuroImage·K J Friston
May 20, 1998·Drug and Alcohol Dependence·M J Selby, R L Azrin
Mar 21, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K J Friston
Mar 24, 2000·European Addiction Research·M SpeckaM Gastpar
May 16, 2000·Brain Research. Cognitive Brain Research·S Weiss, P Rappelsberger
Sep 1, 2000·Journal of Affective Disorders·M D Van den BergJ Ormel
Feb 13, 2001·Trends in Cognitive Sciences·S L. Bressler, J A.S. Kelso
Apr 17, 2001·The Behavioral and Brain Sciences·P L Nunez
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L O Bauer
Feb 22, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Wilson A TruccoloSteven L Bressler
Jan 25, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Alexander A FingelkurtsAlexander Ya Kaplan
May 9, 2003·Brain and Language·Andrew A FingelkurtsMikko Sams
May 28, 2003·Human Brain Mapping·Cornelis J StamBob W van Dijk
Jun 27, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven L Bressler
Dec 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anna G Polunina, Dmitriy M Davydov
Jun 19, 2004·The International Journal of Neuroscience·Andrew A Fingelkurts, Alexander A Fingelkurts
Jun 29, 2004·NeuroImage·Andrew A FingelkurtsSeppo Kähkönen
Aug 28, 2004·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·John E Richards
Oct 27, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna FerrariEmilio Sternieri
Jan 12, 2005·Neuroscience and Biobehavioral Reviews·Andrew A FingelkurtsSeppo Kähkönen
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrew A FingelkurtsSeppo Kähkönen
Feb 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrzej CichockiTakayoshi Kurachi
Apr 27, 2005·Experimental Psychology·Wolfgang KlimeschPaul Sauseng
Sep 10, 2005·Brain Research·Abdulbaki AgbasElias K Michaelis
Jun 17, 2006·Human Brain Mapping·Andrew A FingelkurtsSeppo Kähkönen
Feb 27, 2007·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Alexander A FingelkurtsTaina Autti

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Citations

Jan 11, 2016·Journal of Neuroscience Research·Farid MotlaghHussain Habil
Apr 22, 2015·Acta neurologica Belgica·Grace Y WangBruce R Russell
Oct 11, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Grace Y WangBruce R Russell
Jul 17, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sylco S HoppenbrouwersZafiris J Daskalakis
Jun 13, 2014·Journal of Psychopharmacology·Grace Y WangBruce R Russell
Apr 22, 2017·Frontiers in Human Neuroscience·Hada Fong-Ha Ieong, Zhen Yuan
Jun 14, 2019·Frontiers in Human Neuroscience·Rachel F SmallwoodDonald A Robin

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