Methadone treatment improves tuberculosis treatment among hospitalized opioid dependent patients in Ukraine

The International Journal on Drug Policy
Olga MorozovaFrederick L Altice

Abstract

Ukraine's volatile syndemics of tuberculosis (TB) and HIV among people who inject drugs (PWIDs) introduces numerous treatment challenges for each condition, including high mortality and development of multi-drug resistant TB (MDR-TB). A prospective, non-randomized 90-day observational study was conducted in six Ukrainian TB treatment sites to assess the effectiveness of integrating methadone maintenance (MMT) with TB treatment using: (1) 90-day TB treatment retention; (2) time to treatment discontinuation; (3) TB medication adherence; and (4) subject disposition, including mortality. Of the 110 participants enrolled, 57 received MMT and 53 did not (non-MMT). All of the primary outcomes were significantly better in MMT versus non-MMT groups, including 90-day TB treatment completion (89.5% versus 73.6%; p=0.031), time to TB treatment discontinuation (p=0.039) and TB medication adherence (97.1% versus 86.2%; p<0.001) after controlling for death. The major reasons for treatment non-completion in the non-MMT group included death (N=3), administrative discharge from the clinic (N=5), loss to follow-up (N=2), and arrest (N=4). Overall, 90-day mortality was high (8.2%). After controlling for covariates differing between the two groups ...Continue Reading

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Citations

Dec 10, 2014·Current Opinion in Infectious Diseases·Adeeba Kamarulzaman, Frederick L Altice
Jun 20, 2017·The International Journal on Drug Policy·Iuliia MakarenkoFrederick L Altice
Jun 21, 2019·Current Opinion in HIV and AIDS·Anna P Deryabina, Wafaa M El-Sadr
Jul 19, 2019·Frontiers in Medicine·Jesica Mazza-StalderLaurent Pierre Nicod
May 25, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Gabriel J CulbertFrederick L Altice
Apr 6, 2019·BMC Infectious Diseases·Jørn Henrik VoldLars Thore Fadnes
Mar 1, 2017·Drug and Alcohol Dependence·Olga MorozovaFrederick L Altice

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