Methaemoglobin in man living at high altitude.

British Journal of Haematology
D GourdinN Gutierez

Abstract

Methaemoglobin has been found in the red cells of subjects living permanently at high altitudes (above 3500 m). The level of methaemoglobin appeared to be inversely related to the red cell count and was much increased in anaemic subjects. The methaemoglobinaemia disappeared when the subjects descended to low altitude. The mechanism of this methaemoglobinaemia is not clear. Its presence appears to be related to the hypoxia of altitude, for toxic factors, enzymopenia and the presence of haemoglobin M were eliminated. The regulation of the oxygen dissociation curve in this condition is discussed.

References

Oct 1, 1971·Respiration Physiology·N BancheroJ A Will
Jun 14, 1968·Annals of the New York Academy of Sciences·H HarrisJ Luffman

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Citations

Nov 1, 1975·British Journal of Haematology·R P Smith, L C Ou
Dec 15, 1977·Experientia·C P Olander, C E Parr
Nov 1, 1979·Annals of Human Biology·J ArnaudH Vergnes
Jun 25, 2010·Nitric Oxide : Biology and Chemistry·Claire de BisschopHervé Guénard
Nov 1, 1978·Intensive Care Medicine·D B Hans, M H Jensen

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