Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum

Neuropharmacology
Andrew B ThompsonAlicia Izquierdo

Abstract

Exposure to drugs of abuse can produce many neurobiological changes which may lead to increased valuation of rewards and decreased sensitivity to their costs. Many of these behavioral alterations are associated with activity of D2-expressing medium spiny neurons in the striatum. Additionally, Bdnf in the striatum has been shown to play a role in flexible reward-seeking behavior. Given that voluntary aerobic exercise can affect the expression of these proteins in healthy subjects, and that exercise has shown promise as an anti-addictive therapy, we set out to quantify changes in D2 and Bdnf expression in methamphetamine-exposed rats given access to running wheels. Sixty-four rats were treated for two weeks with an escalating dose of methamphetamine or saline, then either sacrificed, housed in standard cages, or given free access to a running wheel for 6 weeks prior to sacrifice. Rats treated with methamphetamine ran significantly greater distances than saline-treated rats, suggesting an augmentation in the reinforcement value of voluntary wheel running. Transcription of Drd2 and Bdnf was assessed via RT-qPCR. Protein expression levels of D2 and phosphorylation of the TrkB receptor were measured via western blot. Drd2 and Bdnf mR...Continue Reading

References

Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Anh Hai TranTaketoshi Ono
Jul 17, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David S SegalArthur K Cho
Apr 1, 1954·Journal of Comparative and Physiological Psychology·J KAGAN, M BERKUN
Oct 2, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia IzquierdoJohn F Marshall
Dec 22, 2009·Molecular BioSystems·Raquel de Sousa AbreuChristine Vogel
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·David J CreerTimothy J Bussey
Nov 13, 2010·Behavioural Brain Research·Benjamin N GreenwoodMonika Fleshner
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie M GromanJ David Jentsch
Feb 22, 2012·Drug and Alcohol Dependence·Maggie M SweitzerAhmad R Hariri
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Graziana GattoRüdiger Klein
Apr 12, 2013·The International Journal of Neuropsychopharmacology·Benjamin B TournierNathalie Ginovart
Jun 12, 2013·Psychopharmacology·Stephanie M GromanJames David Jentsch
Jun 29, 2013·Neuroscience and Biobehavioral Reviews·Wendy J LynchMark A Smith
Mar 22, 2014·The International Journal of Neuropsychopharmacology·Lisa M McFaddenAnnette E Fleckenstein
Mar 25, 2014·Annals of the New York Academy of Sciences·J David JentschZachary T Pennington
Nov 21, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alexandra StolyarovaAlicia Izquierdo

❮ Previous
Next ❯

Citations

Mar 17, 2016·Neuroscience·Alicia IzquierdoAndrew Holmes
Nov 9, 2016·Stress : the International Journal on the Biology of Stress·Evan E HartAlicia Izquierdo
May 14, 2020·Neural Plasticity·Ella E BauerPeter J Clark
Dec 22, 2017·CNS Neuroscience & Therapeutics·António Pedro Delgado MoraisFrederico Costa Pereira
Apr 9, 2021·Addiction·Fatima Anne PerezJu Lee Oei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.