Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation

Biomolecules & Therapeutics
Buyun KimByoungduck Park

Abstract

Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to drug addiction and causes serious health complications, including attention deficit, memory loss and cognitive decline. These neurological complications are strongly associated with METH-induced neurotoxicity and neuroinflammation, which leads to neuronal cell death. The current review investigates the molecular mechanisms underlying METH-mediated neuronal damages. Our analysis demonstrates that the process of neuronal impairment by METH is closely related to oxidative stress, transcription factor activation, DNA damage, excitatory toxicity and various apoptosis pathways. Thus, we reach the conclusion here that METH-induced neuronal damages are attributed to the neurotoxic and neuroinflammatory effect of the drug. This review provides an insight into the mechanisms of METH addiction and contributes to the discovery of therapeutic targets on neurological impairment by METH abuse.

References

Jun 28, 1992·Annals of the New York Academy of Sciences·D SulzerS Rayport
Apr 29, 1999·Journal of Neuroscience Research·A H StokesK E Vrana
Mar 7, 2001·The American Journal of Psychiatry·N D VolkowE N Miller
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S JayanthiJ L Cadet
Nov 13, 2003·European Journal of Pharmacology·Kristopher M Kahlig, Aurelio Galli
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Subramaniam JayanthiJean Lud Cadet
Sep 15, 2004·Journal of Chemical Neuroanatomy·Xiaohua ShenRandal J Kaufman
Dec 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emmanuel ValjentJean-Antoine Girault
Jul 16, 2005·Harvard Review of Psychiatry·Charles W MeredithAndrew J Saxon
Jan 19, 2006·Journal of Neurochemistry·Robert D Staszewski, Bryan K Yamamoto
Jul 1, 2006·The AAPS Journal·Evan L RiddleGlen R Hanson
Sep 22, 2006·Antioxidants & Redox Signaling·Agnes GörlachThomas Kietzmann
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Mona Johannessen, Ugo Moens
Jan 11, 2007·Annual Review of Pharmacology and Toxicology·Annette E FleckensteinGlen R Hanson
Feb 9, 2007·Journal of Neurochemistry·Gloria LazzeriFrancesco Fornai
Mar 31, 2007·Free Radical Biology & Medicine·Roberta CastinoCiro Isidoro
Aug 9, 2007·Journal of Neurochemistry·David J Eyerman, Bryan K Yamamoto
May 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshimoto SekineJean L Cadet
Jul 5, 2008·European Journal of Pharmacology·Pei-Wen ChuAnnette E Fleckenstein
Nov 11, 2008·Annals of the New York Academy of Sciences·T W RobbinsB J Everitt
Dec 2, 2008·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Ahmed ElkashefJari Tiihonen
Feb 10, 2009·The European Journal of Neuroscience·Jun ChenAnita Sidhu
Jun 23, 2009·Nature Reviews. Neuroscience·Lorenzo GalluzziGuido Kroemer
Nov 10, 2009·International Review of Neurobiology·Jean Lud Cadet, Irina N Krasnova
Nov 27, 2009·The Journal of Pharmacology and Experimental Therapeutics·Teruo HayashiTsung-Ping Su
Jan 28, 2010·The Annals of Thoracic Surgery·Elaine E TsengWilliam A Baumgartner
Mar 6, 2010·Annals of the New York Academy of Sciences·Kyle C Schmitt, Maarten E A Reith
Apr 9, 2010·Journal of Pineal Research·Jiraporn TocharusPiyarat Govitrapong

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Citations

Apr 1, 2021·BMJ Case Reports·Seek Yang LeeMohamed Azlam Mohamed Micdhadhu
Aug 3, 2021·Frontiers in Pharmacology·Jia-Hao LiXiao-Li Xie
Aug 7, 2021·Addictive Behaviors·Kavinash Loganathan
Oct 7, 2021·Applied Biochemistry and Biotechnology·Sara NikeafsharReza Tahvilian

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Methods Mentioned

BETA
protein folding

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