Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection

Frontiers in Microbiology
Uma SriramRaghava Potula

Abstract

Methamphetamine (METH) is a highly addictive psychostimulant that not only affects the brain and cognitive functions but also greatly impacts the host immune system, rendering the body susceptible to infections and exacerbating the severity of disease. Although there is gathering evidence about METH abuse and increased incidence of HIV and other viral infections, not much is known about the effects on the immune system in a chronic viral infection setting. We have used the lymphocytic choriomeningitis virus (LCMV) chronic mouse model of viral infection in a chronic METH environment and demonstrate that METH significantly increases CD3 marker on splenocytes and programmed death-1 (PD-1) expression on T cells, a cell surface signaling molecule known to inhibit T cell function and cause exhaustion in a lymphoid organ. Many of these METH effects were more pronounced during early stage of infection, which are gradually attenuated during later stages of infection. An essential cytokine for T-lymphocyte homeostasis, Interleukin-2 (IL-2) in serum was prominently reduced in METH-exposed infected mice. In addition, the serum pro-inflammatory (TNF, IL12 p70, IL1β, IL-6, and KC-GRO) and Th2 (IL-2, IL-10, and IL-4) cytokine profiles were al...Continue Reading

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Citations

Mar 28, 2018·Cell Death Discovery·Raghava PotulaShongshan Fan
Jun 27, 2018·Pharmacological Reviews·Raul R GainetdinovMark D Berry
Apr 28, 2016·Journal of Neuroinflammation·Nicole C FernandesRaghava Potula
Apr 25, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yan ZhaoMin Zhao
Jul 14, 2020·Frontiers in Immunology·Adonis SferaJose E Campo Maldonado

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Methods Mentioned

BETA
ELISA
PCR
FACS

Software Mentioned

FlowJo
FACS Diva
GraphPad
TreeStar
MSD reader
Prism

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