Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatum.

PloS One
J L CadetAmber B Hodges

Abstract

Methamphetamine (METH) is an illicit drug which is neurotoxic to the mammalian brain. Numerous studies have revealed significant decreases in dopamine and serotonin levels in the brains of animals exposed to moderate-to-large METH doses given within short intervals of time. In contrast, repeated injections of small nontoxic doses of the drug followed by a challenge with toxic METH doses afford significant protection against monoamine depletion. The present study was undertaken to test the possibility that repeated injections of the drug might be accompanied by transcriptional changes involved in rendering the nigrostriatal dopaminergic system refractory to METH toxicity. Our results confirm that METH preconditioning can provide significant protection against METH-induced striatal dopamine depletion. In addition, the presence and absence of METH preconditioning were associated with substantial differences in the identity of the genes whose expression was affected by a toxic METH challenge. Quantitative PCR confirmed METH-induced changes in genes of interest and identified additional genes that were differentially impacted by the toxic METH challenge in the presence of METH preconditioning. These genes include small heat shock 27...Continue Reading

References

Sep 1, 1979·Drug and Alcohol Dependence·G C WagnerC R Schuster
Feb 1, 1976·Drug and Alcohol Dependence·L S SeidenC R Schuster
Oct 1, 1989·Neuropharmacology·M J De Vito, G C Wagner
Jan 1, 1988·Annals of the New York Academy of Sciences·V B Domesick
Aug 1, 1974·Endocrinology·C OliverJ C Porter
Jul 31, 1967·JAMA : the Journal of the American Medical Association·J C KramerD C Littlefield
Oct 29, 1981·The New England Journal of Medicine·A I FadenJ W Holaday
Aug 1, 1995·The Journal of Cell Biology·S M Brady-KalnayN K Tonks
May 23, 1998·Neurochemistry International·J L Cadet, C Brannock
May 25, 1999·Regional Anesthesia and Pain Medicine·G Lederhaas
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M E AndrésG Mandel
Feb 28, 2001·The Journal of Molecular Diagnostics : JMD·M S RajeevanE R Unger
Mar 7, 2001·The American Journal of Psychiatry·N D VolkowE N Miller
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Sep 13, 2001·The European Journal of Neuroscience·M Guerra-CrespoL Pérez-Martínez
Feb 8, 2002·Journal of Addictive Diseases·Sara L SimonWalter Ling
Apr 2, 2002·Nature Genetics·Jianhua ZhangMing Xu
Apr 19, 2002·Molecular Pharmacology·Subramaniam JayanthiJean Lud Cadet
Jul 11, 2002·Brain Research. Molecular Brain Research·Jessie TruettnerMiguel A Pérez-Pinzón
Oct 26, 2002·Science·Victoria V LunyakMichael G Rosenfeld
May 15, 2003·Trends in Neurosciences·Ulrich DirnaglJohn M Hallenbeck

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Citations

Oct 29, 2011·The Journal of Pharmacology and Experimental Therapeutics·Lisa M McFaddenAnnette E Fleckenstein
Feb 14, 2016·Psychopharmacology·Irina N KrasnovaJean Lud Cadet
Mar 31, 2015·Toxicology and Applied Pharmacology·Raúl López-ArnauElena Escubedo
Nov 19, 2011·Journal of Pharmacy Practice·Todd BrackinsJulie C Kissack
Oct 7, 2016·Brain Structure & Function·Devesh MishraCarmela M Reichel
Jul 7, 2011·Dose-response : a Publication of International Hormesis Society·Jean Lud CadetIrina N Krasnova
Jan 13, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jun PaneeLinda Chang
Aug 25, 2018·Oxidative Medicine and Cellular Longevity·Fiona LimanaqiFrancesco Fornai

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Datasets Mentioned

BETA
GSE17665

Methods Mentioned

BETA
PCR

Software Mentioned

Illumina BeadStudio
GeneSpring
BeadStudio
LightCycler Probe Design
StatView

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