Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the rat.

PloS One
Irina N KrasnovaJean Lud Cadet

Abstract

Methamphetamine (meth) is an illicit psychostimulant that is abused throughout the world. Repeated passive injections of the drug given in a single day or over a few days cause significant and long-term depletion of dopamine and serotonin in the mammalian brain. Because meth self-administration may better mimic some aspects of human drug-taking behaviors, we examined to what extent this pattern of drug treatment might also result in damage to monoaminergic systems in the brain. Rats were allowed to intravenously self-administer meth (yoked control rats received vehicle) 15 hours per day for 8 days before being euthanized at either 24 hours or at 7 and 14 days after cessation of drug taking. Meth self-administration by the rats was associated with a progressive escalation of daily drug intake to 14 mg/kg per day. Animals that self-administered meth exhibited dose-dependent decreases in striatal dopamine levels during the period of observation. In addition, there were significant reductions in the levels of striatal dopamine transporter and tyrosine hydroxylase proteins. There were also significant decreases in the levels of dopamine, dopamine transporter, and tyrosine hydroxylase in the cortex. In contrast, meth self-administrat...Continue Reading

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Citations

Jul 31, 2013·Life Sciences·Laura E HalpinBryan K Yamamoto
Mar 4, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Irina N KrasnovaJean L Cadet
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Feb 14, 2016·Psychopharmacology·Irina N KrasnovaJean Lud Cadet
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Mar 1, 2017·Archives of Pharmacal Research·Eun-Joo ShinHyoung-Chun Kim

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Methods Mentioned

BETA
Protein assay

Software Mentioned

Origin
LabWorks
SigmaStat
MED Associates

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