Methamphetamine-stimulated striatal dopamine release declines rapidly over time following microdialysis probe insertion

Brain Research
R R HolsonB Gough

Abstract

To investigate changes in striatal dopamine release over a series of brief methamphetamine (METH) exposures, METH was pulsed three times at 2-h intervals, with the first exposure occurring 2 h after microdialysis probe insertion. Whether METH was administered directly into the striatum via the microdialysate (20 microM of METH for 10 min), or via peripheral intraperitoneal (i.p.) injection (1 mg/kg METH, i.p.), the dopamine (DA) peak elicited by the third METH exposure was only 50% as large as that elicited by the first exposure, 4 h earlier. This decline in the magnitude of METH-induced DA release probably continued over at least 24 h, since the magnitude of a single peak 26 h after probe implantation was only one-seventh of that at 2 h. This reduction in the response to METH was a function of time post-probe insertion, and not of prior METH exposure. Thus, peak size was the same at 6 h post-implantation in animals which received two prior METH pulses or no prior METH pulses, and in both cases this 6-h peak was substantially lower than that at 2 h post-implantation. Circadian influences were also excluded as a factor, because size of the initial METH-induced DA peak did not vary as a function of time of probe implantation. It ...Continue Reading

Citations

Sep 27, 2006·Neurotoxicity Research·Cesar A RomeroMario Herrera-Marschitz
Sep 16, 2005·Nature Reviews. Neuroscience·Catalin V Buhusi, Warren H Meck
Nov 23, 2006·Brain Research·Alejandra M PacchioniPeter W Kalivas
Aug 10, 2013·Analytical Chemistry·Kathryn M NesbittAdrian C Michael
Dec 30, 2014·ACS Chemical Neuroscience·Takashi D Y KozaiX Tracy Cui
Mar 24, 2016·ACS Chemical Neuroscience·Erika L VarnerAdrian Charles Michael

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