PMID: 9426992Jan 14, 1998Paper

Methamphetamine toxicity: treatment with a benzodiazepine versus a butyrophenone

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
J R RichardsD R Duncan

Abstract

Patients with methamphetamine toxicity often present to the emergency department (ED) agitated, violent and psychotic. To determine the efficacy of a benzodiazepine versus a butyrophenone for chemical restraint we conducted a prospective, randomized study at a large urban university ED between January 1995 and January 1997. Patients were randomized to receive either lorazepam or droperidol intravenously. A 6-point sedation scale was devised, with 6 representing extreme agitation and 1 deep sleep. Sedation scores were recorded at time 0, 5, 10, 15, 30 and 60 min. Vital signs were recorded at time 0 and at 60 min. If sedation was inadequate, repeat dosages of each drug could be repeated at 30 min. Toxicology screen, ethanol and creatinine phosphokinase levels were obtained. A total of 146 patients were evaluated. Seventy-four patients received lorazepam and 72 received droperidol. Both drugs had similar sedation profiles at 5 min. Patients receiving droperidol had significantly improved sedation scores at times 10, 15, 30 and 60 min than lorazepam (p < 0.001). More repeat doses of lorazepam were given (26) than droperidol (6) at 30 min. Both drugs produced significant reduction in pulse, systolic blood pressure, respiratory rate,...Continue Reading

Citations

Jun 23, 2000·The Journal of Emergency Medicine·J R Richards
Jan 2, 2007·Pediatric Emergency Care·Anne-Michelle Ruha, Mark C Yarema
Jul 2, 2003·Emergency Medicine Journal : EMJ·A YildizA Turgay
Jun 5, 2002·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·B Zane HorowitzRaymond Moreno
Sep 6, 2000·Journal of Periodontology·J R Richards, B T Brofeldt
Sep 21, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Leo J SchepD Michael G Beasley
Apr 20, 2010·Clinical Therapeutics·Scott L Zeller, Robert W Rhoades
May 12, 2009·Addiction·Christopher C Cruickshank, Kyle R Dyer
Jul 26, 2006·Pharmacotherapy·Frank Romanelli, Kelly M Smith
Dec 22, 1999·The American Journal of Emergency Medicine·J R RichardsR W Derlet
Jan 3, 2006·Annals of Emergency Medicine·Jeremy Brown
Jan 7, 2000·The Psychiatric Clinics of North America·P L ForsterM A Phelps
Jan 9, 2004·Clinics in Chest Medicine·Babak Mokhlesi, Thomas Corbridge
Mar 1, 2015·Drug and Alcohol Dependence·John R RichardsB Zane Horowitz
Aug 18, 2016·British Journal of Clinical Pharmacology·Lee-Kien FooGeoffrey K Isbister
Feb 26, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marina GarrigaEduard Vieta
Mar 30, 2018·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·John R RichardsErik G Laurin
Mar 28, 2006·The Journal of School Nursing : the Official Publication of the National Association of School Nurses·Jacob P GettigIzabella Nowosadzka
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Steven J ShoptawWalter Ling
Jul 3, 2019·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Celene Y L YapUNKNOWN Sedation for Acute Agitation in Emergency Department Patients: Targeting Adverse Events (SIESTA) Collaborative Study Group
Dec 16, 2016·The Cochrane Database of Systematic Reviews·Mariam A Khokhar, John Rathbone
Sep 16, 2017·Journal of Addiction·John R RichardsRobert W Derlet
Sep 6, 2020·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Marc L MartelJon B Cole
Mar 12, 2003·Chest·Babak MokhlesiThomas C Corbridge

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