Abstract
Methanol intoxication causes severe metabolic acidosis and can lead to permanent visual damage or death. Methanol, readily available in common products like antifreeze, is ingested accidentally or deliberately as a substitute for ethanol and in suicide attempts. Because it may become a major fuel source in the 21st century and because industrial uses are expanding, deliberate and accidental intoxication is likely to increase. Rapid diagnosis is essential so that appropriate treatment can be instituted quickly. The authors review the pharmacology, clinical and laboratory findings, and pathology and pathophysiology of methanol intoxication. In addition, they discuss the differential diagnosis and treatment of acute intoxication, including the use of 4-methylpyrazole in preventing the conversion of methanol to formate.
Citations
Mar 31, 1999·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·H E ZimmermanJ W Donovan
Dec 31, 2002·Forensic Science International : Synergy·Nesime YayciSermet Koç
Nov 5, 1997·The Journal of Emergency Medicine·A S Church, M D Witting
Nov 1, 1996·Reproductive Toxicology·S S FuC L Keen
Jan 11, 2000·Critical Care Medicine·T E Albertson
Aug 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A S PetersM-J Hilz
Oct 16, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Yashpal SinghDinesh K Singh
Jan 1, 1993·Chest·M J VogtS A Sahn
Sep 25, 2012·Critical Care Clinics·James A Kruse
Mar 31, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R PoonG Pelletier
Jul 22, 2008·Forensic Science International : Synergy·H AndresenE E Turk
Jun 3, 2004·Resuscitation·Chee-Fah Chong
Jul 7, 1998·Toxicology and Applied Pharmacology·W LiB M Altura
Mar 9, 2012·Forensic Science International : Synergy·José L CascallanaRosario Montes
Mar 1, 1994·Annals of Emergency Medicine·R J BrennanB J Zink
Jan 1, 1992·Intensive Care Medicine·J A Kruse
Jan 27, 2021·Hospital Practice·Charat ThongprayoonWisit Cheungpasitporn