Methanol may function as a cross-kingdom signal.

PloS One
Yuri L DorokhovYuri Y Gleba

Abstract

Recently, we demonstrated that leaf wounding results in the synthesis of pectin methylesterase (PME), which causes the plant to release methanol into the air. Methanol emitted by a wounded plant increases the accumulation of methanol-inducible gene mRNA and enhances antibacterial resistance as well as cell-to-cell communication, which facilitates virus spreading in neighboring plants. We concluded that methanol is a signaling molecule involved in within-plant and plant-to-plant communication. Methanol is considered to be a poison in humans because of the alcohol dehydrogenase (ADH)-mediated conversion of methanol into toxic formaldehyde. However, recent data showed that methanol is a natural compound in normal, healthy humans. These data call into question whether human methanol is a metabolic waste product or whether methanol has specific function in humans. Here, to reveal human methanol-responsive genes (MRGs), we used suppression subtractive hybridization cDNA libraries of HeLa cells lacking ADH and exposed to methanol. This design allowed us to exclude genes involved in formaldehyde and formic acid detoxification from our analysis. We identified MRGs and revealed a correlation between increases in methanol content in the p...Continue Reading

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Citations

Jun 12, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Shu-Ping WangGuo-Qing Li
Jul 25, 2014·Journal of Experimental Botany·Fabien SénéchalJérôme Pelloux
Jul 16, 2014·American Journal of Respiratory and Critical Care Medicine·Paolo MontuschiFrancesca Santamaria
Mar 29, 2014·Frontiers in Plant Science·Tatiana V KomarovaYuri L Dorokhov
Jul 18, 2014·PloS One·Anastasia V ShindyapinaYuri L Dorokhov
Dec 19, 2017·Frontiers in Neuroscience·Anastasia V ShindyapinaYuri L Dorokhov
Jun 14, 2018·Journal of Texture Studies·Davide RabitiAnwesha Sarkar
Mar 4, 2014·PloS One·Tatiana V KomarovaYuri L Dorokhov
Apr 3, 2015·Physiological Reviews·Yuri L DorokhovTatiana V Komarova
Feb 11, 2016·Journal of Breath Research·Martin KistlerJan Rozman
Oct 30, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Yuri L DorokhovTatiana V Komarova

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Datasets Mentioned

BETA
FLJ95049
A4D196
AAI04784.1

Methods Mentioned

BETA
PCR

Software Mentioned

AliBee

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