Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats

Asian Pacific Journal of Tropical Medicine
O A AdaramoyeMoosavi-Movahedi Ali

Abstract

To justify the use of African mistletoe (AM) Viscum album (V. album) in folkoric medicine to treat diabetes. In one experiment, the fasting blood glucose (FBG) levels of diabetic rats were monitored for 4 h. Diabetic rats were treated with AM at doses of 50 mg/kg (AM1) and 100 mg/kg (AM2), glibenclamide (GB) (positive control) and saline solution (SS). In another experiment, diabetic rats were treated with AM2, GB and SS daily for 3 weeks. AM1 and AM2 elicited significant (P<0.05) hypoglycaemic effects within 4 h of extract administration. AM1 and AM2 decreased the FBG by 41% and 49%, respectively, at 2 h. AM2 was found to lower FBG by 51%, relative to baseline, which was comparable to GB at 3 h. In the second experiment, AM2 and GB significantly (P<0.05) decreased the FBG by 34% and 51%, respectively. This was followed by marked decrease in levels of HbA1C in AM2- and GB- treated diabetic rats. AM2 significantly (P<0.05) decreased the STZ-induced increase in levels of serum triglyceride, urea, lactate dehydrogenase, α-amylase and low-density lipoprotein-cholesterol. Furthermore, diabetic rats treated with AM2 had significantly (P<0.05) elevated high-density lipoprotein-cholesterol. In contrast, STZ administration produced insi...Continue Reading

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Citations

Feb 25, 2014·Journal of Physiology and Biochemistry·Olusola Olalekan ElekofehintiJoão Batista Teixeira Rocha
Mar 31, 2015·Natural Product Research·Jolanta Nazaruk, Przemysław Orlikowski
Sep 15, 2012·Journal of Ethnopharmacology·Adebayo Gbolade
Aug 19, 2015·Journal of Ethnopharmacology·Arezou RezaeiMitra Khademi
Nov 6, 2013·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Xichao XiaShipeng Xue
Mar 29, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Megan L SteeleFriedemann Schad
Mar 2, 2018·Therapeutic Advances in Endocrinology and Metabolism·Sudhanshu Kumar BhartiAwanish Kumar
Jul 6, 2020·Archives of Pharmacal Research·Anna SzurpnickaArkadiusz Szterk
Feb 25, 2021·Journal of Bioenergetics and Biomembranes·Meltem ErdaşDilek Burukoğlu Dönmez
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wioleta Pietrzak, Renata Nowak

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