Methemoglobin in hypoxic rats

Experientia
C P Olander, C E Parr

Abstract

Methemoglobin levels have been found to vary with altitude and to shift the hemoglobin-oxygen dissociation curve. In this study, hematocrits and methemoglobin levels were monitored in rats exposed to hypoxia (420 torr absolute) for various intervals. Hematocrits gradually increased throughout the period of hypoxia, while methemoglobin levels rose by 12 h, peaked at 24 h and returned to control level by day 6. These data, in the context of other work, suggest that increased methemoglobin is important in acclimation to hypoxia.

References

Feb 1, 1975·British Journal of Haematology·D GourdinN Gutierez
Jan 1, 1974·Annual Review of Medicine·G J Brewer
Nov 29, 1974·Annals of the New York Academy of Sciences·J W Eaton
Jun 1, 1973·Journal of Applied Physiology·P W RandW H Austin
Jan 1, 1972·The American Journal of Physiology·C P Olander
Dec 1, 1969·Scandinavian Journal of Clinical and Laboratory Investigation·G Duc, K Engel
Dec 1, 1968·The Journal of Clinical Investigation·C LenfantJ Faura
Sep 23, 1948·The New England Journal of Medicine·C Finch

Citations

Jun 6, 2016·Acta histochemica·Emilia B PetrovaDimitar S Kadiysky
Aug 5, 2004·NTM·Jürgen Schönbeck
Jul 1, 1989·British Journal for the History of Science·M R Oster

Related Concepts

Adaptation, Physiological
Altitude
Metazoa
Anoxemia
Atmosphere Exposure Chambers
Hematocrit Procedure
Methemoglobinemia
Rats, Laboratory

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