Methicillin-resistant Staphylococcus aureus: an evolving pathogen

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Martin E Stryjewski, G Ralph Corey

Abstract

The horizontal transmission of methicillin resistance to Staphylococcus aureus (MRSA) in hospital and community settings, and growing prevalence of these strains, presents a significant clinical challenge to the management of serious infections worldwide. While infection control initiatives have stemmed the rising prevalence, MRSA remains a significant pathogen. More recently, evidence that MRSA is becoming resistant to glycopeptides and newer therapies raises concern about the use of these therapies in clinical practice. Vancomycin resistance has become evident in select clinical settings through rising MICs, growing awareness of heteroresistance, and emergence of intermediate-resistant and fully resistant strains. While resistance to linezolid and daptomycin remains low overall, point mutations leading to resistance have been described for linezolid, and horizontal transmission of cfr-mediated resistance to linezolid has been reported in clinical isolates. These resistance trends for newer therapies highlight the ongoing need for new and more potent antimicrobial therapies.

References

Oct 4, 1975·Lancet·F H Kayser
Sep 1, 1975·American Journal of Clinical Pathology·C C Blackwell, D S Feingold
Aug 1, 1991·The Journal of Hospital Infection·C A MackintoshB A Bannister
Sep 16, 1991·The American Journal of Medicine·R P WenzelM A Pfaller
May 4, 1989·The New England Journal of Medicine·W Brumfitt, J Hamilton-Miller
Jan 1, 1988·The Journal of Antimicrobial Chemotherapy·P Van der AuweraM Husson
Sep 28, 1985·Lancet·M T CafferkeyC T Keane
Oct 1, 1987·Medical History·L G Wilson
Jul 1, 1984·The Journal of Infection·C T Keane, M T Cafferkey
May 1, 1981·Antimicrobial Agents and Chemotherapy·B Hartman, A Tomasz
Jul 1, 1997·The Journal of Antimicrobial Chemotherapy·K HiramatsuF C Tenover
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G LinaJ Etienne
Jan 20, 2000·Antimicrobial Agents and Chemotherapy·S Boyle-VavraR S Daum
Jun 27, 2001·Lancet·C L WieldersA C Fluit
Oct 6, 2001·The Medical Journal of Australia·M WhitbyG Berry
Mar 13, 2002·Science·Nicholas P J DayEdward J Feil
Apr 12, 2002·The Lancet Infectious Diseases·Duarte C OliveiraHermínia de Lencastre
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark C EnrightBrian G Spratt
Aug 17, 2002·Infection and Immunity·Sharon J PeacockNicholas P J Day
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philippe DufourHervé Richet
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E CosgroveYehuda Carmeli
Feb 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott K FridkinUNKNOWN Vancomycin-Intermediate Staphylococcus aureus Epidemiology Study Group
Nov 24, 1955·The New England Journal of Medicine·M FINLAND
Jan 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick G P CharlesM Lindsay Grayson
Jul 10, 2004·American Journal of Respiratory and Critical Care Medicine·Alain CombesUNKNOWN PNEUMA Trial Group
Sep 10, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chih-Chien WangL K Siu
Jun 21, 2005·Emerging Infectious Diseases·Matthew J KuehnertDaniel B Jernigan
Jun 21, 2005·Emerging Infectious Diseases·Xiao Xue MaKeiichi Hiramatsu
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Ralph ZaharUNKNOWN Outcomerea Study Group
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arnaud de LassenceDidier Dreyfuss
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ulrich SeyboldHenry M Blumberg
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean B PatelFred C Tenover
Aug 18, 2006·The New England Journal of Medicine·Gregory J MoranUNKNOWN EMERGEncy ID Net Study Group

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Citations

Feb 12, 2015·Antimicrobial Resistance and Infection Control·Elizabeth ShortMilena McLaughlin
Jul 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Manuel J Favela-HernándezMaría del Rayo Camacho-Corona
Nov 11, 2015·The Journal of Antimicrobial Chemotherapy·Han-Chu ChangHao-Chieh Chiu
Jan 7, 2016·Bioorganic & Medicinal Chemistry Letters·Erika LeemansShahriar Mobashery
Dec 19, 2015·International Forum of Allergy & Rhinology·Amanda J DrillingSarah Vreugde
Mar 13, 2015·Pathology·Deborah A WilliamsonGraeme Nimmo
Jul 22, 2014·IUBMB Life·Jennifer FishovitzShahriar Mobashery
Jul 22, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P D ZiakasE Mylonakis
Dec 9, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Alessandro BartoloniGian Maria Rossolini
Apr 12, 2015·Biochemical and Biophysical Research Communications·Jingang AnJianwen Ren
Sep 26, 2015·British Dental Journal·N BeacherJ Bagg
Aug 15, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shinya InomataMitsuo Kaku
Jul 6, 2015·International Journal of Antimicrobial Agents·Stefania StefaniGiovanni Pacini
Aug 25, 2015·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·José Procópio M SennaRicardo Galler
Aug 19, 2015·Frontiers in Microbiology·Shankar ThangamaniMohamed N Seleem
Mar 19, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J LegrandD Guillemot
Jun 4, 2015·Annual Review of Biochemistry·Sharon J Peacock, Gavin K Paterson
Mar 31, 2015·Cell Host & Microbe·Katie MaurerKen Cadwell
Jun 22, 2016·ACS Medicinal Chemistry Letters·Inmaculada Rentero RebolloChristian Heinis
Mar 31, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Marco FalconeMario Venditti
Apr 19, 2015·BMC Genomics·Marina SantiagoTimothy C Meredith
Dec 5, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G Ralph CoreySteven L Barriere
Jul 2, 2016·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Angélica CechinelLuciano Z Goldani
Jul 26, 2016·Frontiers in Microbiology·Ana P Sant'Anna da SilvaVera L de Menezes Lima
Sep 23, 2016·European Journal of Medicinal Chemistry·Yugen ZhuXiang Wang
Oct 27, 2015·Annals of the New York Academy of Sciences·Truc T TranCesar A Arias
Nov 6, 2015·PLoS Pathogens·Aisling F BrownRachel M McLoughlin
Jul 2, 2015·Einstein·Camila Delfino Ribeiro da Silva, Moacyr Silva Júnior
Apr 13, 2017·Expert Opinion on Drug Discovery·Wooseong KimEleftherios Mylonakis

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