Methicillin-resistant Staphylococcus aureus in Intensive Care Unit Setting of India: A Review of Clinical Burden, Patterns of Prevalence, Preventive Measures, and Future Strategies

Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Yatin MehtaRishi Jain

Abstract

The aim of this review article is not only to analyze the clinical burden of methicillin-resistant Staphylococcus aureus (MRSA) in intensive care unit (ICU) setting of India, along with the patterns of prevalence and its prevention measures, but also to focus on the new anti-MRSA research molecules which are in late stage of clinical development. Methicillin resistance is reported to be present in 13-47% of Staphylococcus aureus infections in India. Therapeutic options to combat MRSA are becoming less, because of emerging resistance to multiple classes of antibiotics. Intensive care units are the harbinger of multidrug-resistant organisms including MRSA and are responsible for its spread within the hospital. The emergence of MRSA in ICUs is associated with poor clinical outcomes, high morbidity, mortality, and escalating treatment costs. There is an urgency to bolster the antibiotic pipeline targeting MRSA. The research efforts for antibiotic development need to match with the pace of emergence of resistance, and new antibiotics are needed to control the impending threat of untreatable MRSA infections. Fortunately, several potential antibiotic agents are in the pipeline and the future of MRSA management appears reassuring. The ...Continue Reading

References

May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark C EnrightBrian G Spratt
Apr 9, 2005·The New England Journal of Medicine·Scott K FridkinUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Apr 4, 2006·The Journal of Hospital Infection·J E CoiaUNKNOWN Infection Control Nurses Association
Oct 5, 2007·The Journal of Antimicrobial Chemotherapy·Michael A BorgUNKNOWN ARMed Project Members and Collaborators
Dec 30, 2008·The Journal of Emergency Medicine·Jonathan Kei, John R Richards
Dec 31, 2009·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Lahari SaikiaMili Sarkar
Apr 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew S LubinYoav Golan
May 17, 2011·Journal of Global Infectious Diseases·Dechen C TseringSumit Kar
Oct 4, 2012·Indian Journal of Pathology & Microbiology·Vaishali U ThoolBharat J Wadher
Apr 2, 2013·Journal of Clinical and Diagnostic Research : JCDR·Sharon Rainy RongpharpiHitesh Kalita
Jul 31, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Vandana Kalwaje EshwaraChiranjay Mukhopadhyay
Oct 18, 2013·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Priya DattaJagdish Chander
Nov 2, 2013·Journal of Clinical and Diagnostic Research : JCDR·Arunava KaliSreenivasan Srirangaraj
Jan 15, 2014·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Thomas C HaveyNick Daneman
Jun 13, 2015·Journal of Global Infectious Diseases·Dardi Charan Kaur, Sadhana Sanjay Chate
Jun 1, 2016·The Indian Journal of Medical Research·Neerja JindalSatvir Kaur
Jun 1, 2018·Nature Reviews. Disease Primers·Andie S LeeStephan Harbarth

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