Methicillin-resistant Staphylococcus aureus: microbiologic characteristics, antimicrobial susceptibilities, and assessment of virulence of an epidemic strain

The Journal of Infectious Diseases
J E PeacockG L Mandell

Abstract

An epidemic strain of methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients at the University of Virginia Hospital in Charlottesville (MRSA-Va) was characterized, and virulence properties were compared with those of three clinically significant strains of methicillin-sensitive S. aureus. Unlike most known strains of MRSA, MRSA-Va was sensitive to tetracycline and streptomycin and exhibited high-level homogeneous methicillin resistance (minimal inhibitory concentration, greater than 128 microgram/ml). The expression of resistance was not influenced by incubation temperature. MRSA-Va contained significantly more catalase (P less than 0.05) than methicillin-sensitive strains but about the same amount of protein A. Phagocytosis and killing of MRSA-Va by normal polymorphonuclear leukocytes were not significantly different from that of the Wood-46 strain of S. aureus. In mouse virulence studies using both intraperitoneal and intravenous modes of infection, 50% lethal doses for MRSA-Va were comparable with those of the three methicillin-sensitive strains. This epidemic strain of MRSA appears to be fully virulent.

Citations

Feb 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y Sumita, S Mitsuhashi
Jan 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A VossI Braveny
Apr 1, 1995·International Journal of Antimicrobial Agents·A Voss, B N Doebbeling
Jun 1, 1997·International Journal of Antimicrobial Agents·F J Schmitz, M E Jones
Feb 12, 2002·European Journal of Internal Medicine·D TalonJ L. Dupond
May 31, 1984·The New England Journal of Medicine·J N Sheagren
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M MelzerS Chinn
Jan 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B N KreiswirthM H Levi
Aug 26, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R CameronAnton Y Peleg
Jan 1, 1990·Society for Applied Bacteriology Symposium Series·B Cookson, I Phillips
Oct 1, 1988·Australian Paediatric Journal·A Y Tam, C Y Yeung
Jan 1, 1986·Antimicrobial Agents and Chemotherapy·B J Hartman, A Tomasz
Sep 1, 1987·Antimicrobial Agents and Chemotherapy·J M Boyce, A A Medeiros
Feb 1, 1988·Antimicrobial Agents and Chemotherapy·M Mateos-MoraJ A Washington
Sep 6, 1986·British Medical Journal·P J Sanderson
Mar 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Mekontso-DessapD Loisance
Feb 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vance G FowlerSharon J Peacock
Nov 27, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Dardi Charan Kaur, Pandey Aastha Narayan
Dec 1, 1991·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·D Mathieu, V Picard
Nov 4, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gerrit KuhnDominique S Blanc
Mar 1, 1986·The Journal of Hospital Infection·M W Casewell
Mar 1, 1986·The Journal of Hospital Infection·F A Waldvogel
Mar 1, 1984·The American Journal of Medicine·T L TreadwellW R McCabe
Jul 1, 1984·The Journal of Infection·C T Keane, M T Cafferkey
Jun 21, 2005·Diagnostic Microbiology and Infectious Disease·Thomas P Lodise, Peggy S McKinnon
Oct 27, 1999·The Journal of Veterinary Medical Science·S I PakA Shimizu
Feb 13, 2001·The Journal of Hospital Infection·B Rubinovitch, D Pittet
Jun 6, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M GiménezV Ausina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.