PMID: 12773128May 30, 2003Paper

Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis

The Journal of Endocrinology
C A IşmanI Alican

Abstract

Depression of metabolism by hypothyroidism decreases oxidant production and thus protects tIssues against oxidant damage. Moreover, it is well-known that abnormal gut motility is a common manifestation in hypo/hyperthyroidism. In this study, we aimed to investigate the putative beneficial effects of methimazole on oxidative injury and dysmotility in a rat colitis model. Methimazole (0.04%) was administered in drinking water starting 15 days prior to induction of colitis. Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid (30 mg/ml; 0.8 ml) in ethanol. Six days after the induction of colitis, the fecal output was measured and used as an index for colonic motility. All rats were decapitated on the seventh day. The distal colon was weighed and the mucosal lesions were scored. Colonic lipid peroxidation (LP) and glutathione (GSH) measurements were performed. The macroscopic score, the colonic wet weight and LP values of the euthyroid colitis group were found to be higher than those of the control group (P<0.05-0.001). All these parameters were reduced in the methimazole-treated colitis group (P<0.01-0.001). The decrease in colonic GSH levels in the colitis group was completely abolished in the methi...Continue Reading

Citations

Feb 9, 2016·Canadian Journal of Physiology and Pharmacology·Amr M Abbas, Hussein F Sakr
Apr 24, 2012·The Journal of Surgical Research·Sina RahimpourAhmad Reza Dehpour
Jun 17, 2010·European Journal of Pharmacology·Uruguaysito BenavidesLeonard D Kohn
Nov 12, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jucimara BaldissarelliMaria R C Schetinger
Feb 16, 2017·Journal of Crohn's & Colitis·Hassan MelhemIsabelle Frey-Wagner
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Steen Joop BonnemaLaszlo Hegedüs
Mar 13, 2016·The Journal of Biological Chemistry·Kellie E CunninghamKevin P Mollen

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