PMID: 9637222Jun 24, 1998Paper

Methimazole-mediated enhancement of albendazole oral bioavailability and anthelmintic effects against parenteral stages of Trichinella spiralis in mice: the influence of the dose-regime

Veterinary Parasitology
M L Lopez-GarciaFrancisco Bolás

Abstract

The influence of methimazole (MTZ) inhibitor of the microsomal oxidases on the systemic availability of the albendazole sulpho-metabolites (ABZS-MT) albendazole-sulphoxide (ABZSO) and albendazole-sulphone (ABZSO2) and on its anthelmintic effects was investigated in a mouse model for helminthic infections. Plasma concentrations of the ABZS-MT were measured by high performance liquid chromatography (HPLC) following treatment of Swiss CD-1 mice with albendazole (ABZ) alone or ABZ plus MTZ, at both single and repeated doses. The anthelmintic effects were assessed in age-matched mice similarly treated following infection with Trichinella spiralis. MTZ significantly (p < 0.01) increased the ABZS-MT plasma concentrations although the pharmacokinetic profile varied greatly according to the dose of ABZ administered. When ABZ was given at a single dose of 50 mg/kg followed by MTZ at 3 mg/kg, a cumulative effect was observed in the ABZS-MT plasma levels with pharmacokinetic parameters (Tmax = 24 h, Cmax= 30.88 microg/ml and AUC = 1120.80 microg h/ml) significantly ( p < 0.01) higher than those following administration of ABZ alone (Tmax = 3 h, Cmax = 11.00 microg/ml and AUC = 268.03 microg h/ml). This cumulative effect was absent followin...Continue Reading

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Citations

Mar 17, 2004·International Journal of Pharmaceutics·K Daniel-MwambeteJ J Torrado
Mar 1, 2002·Toxicology Letters·Uday BandyopadhyayRanajit K Banerjee
Jan 16, 2003·International Journal of Pharmaceutics·Juan José GarcíaJuan José Torrado
Apr 16, 2009·Journal of Helminthology·I Fairweather
Dec 28, 1999·Drug Development and Industrial Pharmacy·J A CastilloJ J Torrado
Aug 2, 2002·Expert Opinion on Pharmacotherapy·Jean Dupouy-CametEdoardo Pozio
Aug 9, 2005·Bioorganic & Medicinal Chemistry·Anelia Ts MavrovaMitka K Micheva
Mar 21, 2015·International Journal of Biological Macromolecules·Ana V CodinaLucila I Hinrichsen
Jul 5, 2021·The Korean Journal of Parasitology·Jong-Yil ChaiSung-Jong Hong

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