Methionine restriction affects the phenotypic and transcriptional response of rainbow trout (Oncorhynchus mykiss) to carbohydrate-enriched diets

The British Journal of Nutrition
Paul M Craig, Thomas W Moon

Abstract

Mammalian studies report that methionine restriction (MR) as a dietary regimen extends life span, delays the onset of age-related diseases and enhances fat oxidation in obese subjects with metabolic syndromes. However, the underlying cellular signalling pathways are poorly understood. Rainbow trout (Oncorhynchus mykiss) is a glucose-intolerant species, providing an excellent model for the study of carbohydrate metabolism. MR diets in combination with 12 % (+/-) and 22 % (+/-) carbohydrate-rich meals were fed to rainbow trout for a period of 8 weeks and phenotypic and transcript expression changes in the liver and white muscle were assessed. Fish fed MR diets, irrespective of carbohydrate load, were shown to abolish the glucose-intolerant phenotype 6 h post-feeding. There was a distinct switch in glucose and glycogen content in the liver of fish fed MR diets, with a significantly higher concentration of glycogen, suggesting reduced glycolytic capacity. Transcriptional responses to MR demonstrated decreased expression of hepatic fatty acid synthase, sterol regulatory binding protein 1, PPARγ coactivator 1-α and PPARα, indicative of a reduction in the de novo synthesis of fatty acids and cholesterol, and a potential decrease in he...Continue Reading

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Citations

Jun 26, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Paul M CraigThomas W Moon
Nov 8, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S Polakof, S Panserat
May 4, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Cristina Otero-RodiñoJosé L Soengas
May 13, 2017·The Journal of Experimental Biology·Cristina VelascoJosé L Soengas
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