Methionine Restriction and Cancer Biology

Nutrients
Desiree WandersXiangming Ji

Abstract

The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the role of glutathione formation, polyamine synthesis, and methyl group donation as mediators of the effects of methionine restriction on cancer biology. The translational potential of the use of methionine restriction as a personalized nutritional approach for the treatment of patients with cancer is also discussed.

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Citations

Oct 12, 2020·Cell Biochemistry and Biophysics·Olga Dotsenko, Dmytro Shtofel
Nov 11, 2020·ELife·Jefte M DrijversMarcia C Haigis
Sep 15, 2020·Expert Opinion on Drug Delivery·Luigia RossiMauro Magnani
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Feb 13, 2021·Metabolites·Linda Lauinger, Peter Kaiser
Jan 18, 2021·The Journal of Biological Chemistry·Adhish S WalvekarSunil Laxman
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga Kazimierska, Urszula Kalinowska-Lis
Jun 11, 2021·Annual Review of Cancer Biology·Luke T IzzoKathryn E Wellen

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