Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

Cell Reports
Clea BárcenaCarlos López-Otín

Abstract

Dietary intervention constitutes a feasible approach for modulating metabolism and improving the health span and lifespan. Methionine restriction (MR) delays the appearance of age-related diseases and increases longevity in normal mice. However, the effect of MR on premature aging remains to be elucidated. Here, we describe that MR extends lifespan in two different mouse models of Hutchinson-Gilford progeria syndrome (HGPS) by reversing the transcriptome alterations in inflammation and DNA-damage response genes present in this condition. Further, MR improves the lipid profile and changes bile acid levels and conjugation, both in wild-type and in progeroid mice. Notably, treatment with cholic acid improves the health span and lifespan in vivo. These results suggest the existence of a metabolic pathway involved in the longevity extension achieved by MR and support the possibility of dietary interventions for treating progeria.

Citations

Mar 23, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jin Young LeeChen-Yu Liao
Jun 18, 2019·Obesity·Shaligram SharmaDesiree Wanders
Feb 13, 2020·Cells·Ray Kreienkamp, Susana Gonzalo
Mar 7, 2020·Nutrients·Desiree WandersXiangming Ji
Jun 23, 2020·EMBO Reports·Maja C FunkMichael Boutros
Jul 28, 2019·Aging·Mélanie ViltardGérard Friedlander
Aug 14, 2020·Physiological Reviews·Alessia PerinoKristina Schoonjans
Sep 14, 2019·Nature Reviews. Cancer·Sydney M SandersonJason W Locasale
Jul 25, 2019·Nature Medicine·Clea BárcenaCarlos López-Otín
Feb 20, 2019·International Journal of Molecular Sciences·Francesca ChiariniGiovanna Lattanzi
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Paulina FalcónSoledad Matus
May 16, 2019·Journal of Zhejiang University. Science. B·Li-Hua JinWen-Dong Huang
Nov 13, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nagarajan MaharajanGoang-Won Cho
Dec 11, 2020·Cell Death Discovery·Francesca CastoldiFederico Pietrocola
Feb 13, 2021·Biomedicines·Munehiro KitadaDaisuke Koya
Dec 9, 2020·International Journal of Molecular Sciences·Carla Almendáriz-PalaciosZoe E Gillespie
Feb 13, 2021·Metabolites·Linda Lauinger, Peter Kaiser
Nov 6, 2020·The World Journal of Men's Health·Andrzej BartkeJustin Darcy
Oct 7, 2020·Biochemical and Biophysical Research Communications·Kyunggon KimMin-Ji Kang
Feb 23, 2021·Environmental and Molecular Mutagenesis·Katherine F WallisIsabelle R Miousse
Aug 4, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Luanfeng WangXuebo Liu
Apr 12, 2021·Briefings in Bioinformatics·Anqiang JiaYi Wang
Apr 24, 2021·Developmental Cell·Ayse Sena MutluMeng C Wang
May 19, 2021·Nature Communications·Victoria A Acosta-RodríguezJoseph S Takahashi
Jul 18, 2021·Trends in Molecular Medicine·Matthias RieckherBjörn Schumacher
Aug 13, 2021·Journal of Cell Science·Chayki ChararDaniel Z Bar

❮ Previous
Next ❯

Methods Mentioned

BETA
metabolomic profiling
ELISA
Assay

Software Mentioned

RMAExpress
GraphPad Prism
limma
RStudio
R
GSEA
MetaboAnalyst
Bioconductor
GSEA NES

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine
F R Margolin, H L Steinbach
© 2022 Meta ULC. All rights reserved