Methionine sulfoxide is transported by high-affinity methionine and glutamine transport systems in Salmonella typhimurium.

Journal of Bacteriology
P D Ayling

Abstract

Three lines of evidence indicated that methionine sulfoxide is transported by the high-affinity methionine and glutamine transport systems in Salmonella typhimurium. First, methionine-requiring strains (metE) which have mutations affecting both of these transport systems (metP glnP) were unable to use methionine sulfoxide as a source of methionine. These strains could still grow on L-methionine because they possessed a low-affinity system (or systems) which transported L-methionine but not the sulfoxide. A methionine auxotroph with a defect only in the metP system, which was dependent upon the glnP+ system for the transport of methionine sulfoxide, was inhibited by L-glutamine because glutamine inhibited the transport of the sulfoxide by the glnP+ system. Second, a metE metP glnP strain could be transduced at either the metP or glnP genes to restore its ability to grow on methionine sulfoxide. Third, the transport of [14C]methionine sulfoxide was inhibited by methionine and by glutamine in the metP+ glnP+ strain. No transport was detected in the metP glnP double-mutant strain.

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Citations

Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·D R Liu, P G Schultz
Nov 1, 1983·The British Journal of Nutrition·A Aksnes, L R Njaa
Jan 1, 1989·Molecular & General Genetics : MGG·A N Cottam, P D Ayling
Jan 1, 1991·Progress in Biophysics and Molecular Biology·I G OldI Saint Girons
Sep 1, 1983·Microbiological Reviews·K E Sanderson, J R Roth
Dec 22, 1982·Biochimica Et Biophysica Acta·V Ganapathy, F H Leibach
Jan 1, 2006·EcoSal Plus·Elise R Hondorp, Rowena G Matthews

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