Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism

The Hematology Journal : the Official Journal of the European Haematology Association
O SalomonU Seligsohn

Abstract

Hyperhomocysteinemia is a defined risk factor for venous thromboembolism (VTE). Several polymorphisms of genes encoding for enzymes acting in the remethylation pathway of homocysteine metabolism, ie, methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C, can cause increased homocysteine levels particularly in patients with deficiencies of folic acid, vitamin B6, or B12 and hence be potential risk factors for VTE. Indeed, homozygous MTHFR C677T was shown to be a mild risk factor for VTE by some, but not by all, investigators. In this study, we assessed the risk exerted by MS A2756G and MTHFR A1298C in a cohort of patients with idiopathic venous thromboembolism. Homozygosities for MS A2756G and MTHFR A1298C were not found to be statistically significant risk factors for VTE. In addition, no interactions were observed among MS A2756G, MTHFR A1298C and MTHFR C677T in conferring a risk of VTE.

Citations

Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·M Den HeijerR Clarke
Apr 12, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·José Ramón González-PorrasJesús San Miguel
Sep 19, 2008·Clinical Orthopaedics and Related Research·Juergen RingwaldRocco P Pitto
Jul 31, 2008·Current Opinion in Pulmonary Medicine·Joel G Ray
Nov 24, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Shaik Mohammad NaushadAkella Radha Rama Devi

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