Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice.

Molecular Genetics and Metabolism
Liyuan DengRima Rozen

Abstract

Low dietary folate and polymorphisms in genes of folate metabolism can influence risk for pregnancy complications and birth defects. Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme. A polymorphism in MTRR (p.I22M), present in the homozygous state in 25% of many populations, may increase risk for neural tube defects. To examine the impact of MTRR deficiency on early development and congenital heart defects, we used mice harboring a gene-trapped (gt) allele in Mtrr. Female mice (Mtrr(+/+), Mtrr(+/gt), and Mtrr(gt/gt)) were mated with male Mtrr(+/g) mice. Reproductive outcomes and cardiac phenotype (presence of defects and myocardial thickness) were assessed at E14.5. Mtrr-deficient mothers had more resorptions and more delayed embryos per litter (resorptions per litter: 0.29+/-0.13; 1.21+/-0.41; 1.87+/-0.38 and delayed embryos per litter: 0.07+/-0.07; 0.14+/-0.14; 0.60+/-0.24 in Mtrr(+/+), Mtrr(+/gt), and Mtrr(gt/gt) mothers respectively). Placentae of Mtrr(gt/gt) mothers were smaller and their embryos were smaller, with myocardial hypoplasia and a higher incidence of ventricular septal defects (VSD) per litter (0; 0.57+/-0.30; 1.57+/-0.67 in Mtr...Continue Reading

References

May 1, 1995·Pediatric Cardiology·J I Hoffman
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·T H RosenquistJ Selhub
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·P J Bagley, J Selhub
Dec 10, 1999·The Journal of Pediatrics·L KapustaT K Eskes
May 3, 2000·American Journal of Epidemiology·L D BottoJ D Erickson
Nov 14, 2000·Circulation Research·S A FisherD Srivastava
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simonetta FrisoJacob Selhub
Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Dec 14, 2002·Genesis : the Journal of Genetics and Development·Simon J ConwaySrinagesh V Koushik
Dec 22, 2004·Pediatric Research·Adriana C Gittenberger-de GrootRobert E Poelmann
Jun 28, 2005·Molecular Genetics and Metabolism·Valerie B O'LearyUNKNOWN Members of the Birth Defects Research Group
Jan 7, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deqiang LiRima Rozen
Feb 7, 2006·Journal of the American College of Cardiology·Charlotte A HobbsMario A Cleves
Apr 1, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Weizhi ZhaoCharlotte A Hobbs
Apr 14, 2006·Hormone Research·A L FowdenM Constancia
Oct 7, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ivon J M van der LindenHenk J Blom
Nov 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Ingrid M van BeynumHenk J Blom
Nov 25, 2006·European Journal of Nutrition·Anna C Verkleij-HagoortRégine P M Steegers-Theunissen
Feb 28, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T H RosenquistR H Finnell
Mar 21, 2007·Molecular Genetics and Metabolism·C Lee ElmoreRowena G Matthews

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Citations

Jun 6, 2009·BMC Medical Genetics·Gary M ShawRichard H Finnell
Jul 16, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah G ObicanAnthony R Scialli
Sep 13, 2013·Nutrients·Maira A Moreno-GarciaLoydie A Jerome-Majewska
Apr 6, 2012·Cardiology in the Young·Karen E ChristensenRima Rozen
Jun 21, 2011·Molecular Biology Reports·Kamil K HozyaszPawel P Jagodzinski
Sep 27, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Karen E ChristensenRima Rozen
Sep 22, 2009·Molecular Genetics and Metabolism·Laurie E ProfitlichShubhika Srivastava
Jan 2, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Muriel J Harris
Oct 1, 2010·Maternal & Child Nutrition·Katalin FeketeTamás Decsi
Jan 3, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jiang Su, Zhongzhi Li
Dec 19, 2019·Molecular Genetics & Genomic Medicine·Chen LyuUNKNOWN National Birth Defects Prevention Study
Sep 25, 2019·Cold Spring Harbor Perspectives in Biology·Jacinta Isabelle Kalisch-SmithDuncan Burnaby Sparrow
Oct 6, 2021·Critical Reviews in Biochemistry and Molecular Biology·Jean-Louis GuéantDavid Coelho
Oct 8, 2013·Cell Metabolism·Eric L Greer, Yang Shi

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