Method-based differences in the automated analysis of the three-dimensional morphology of trabecular bone

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
C A Simmons, J A Hipp

Abstract

The three-dimensional (3D) morphology of trabecular bone is frequently quantified using computer programs. However, there are no standardized implementations of morphology programs and many variations are possible. Even though programs may use the same basic method, results can be significantly different because of differences in implementation. Morphology data from different laboratories therefore may not be comparable. The method of directed secants, with parallel plate assumptions, is commonly used to quantify 3D morphology. We examined the effect of several variations in the implementation of this method on measurements of trabecular plate number (Tb.N), trabecular thickness, and trabecular spacing. Three-dimensional micromagnetic resonance images of 10 bovine trabecular bone specimens were analyzed using several variations of the directed secant method. An analysis of covariance with repeated measures suggested that variations in the algorithm used to count test line intersections, variations in the criteria used to classify a test coordinate as bone or marrow, and variations in the number of test grid rotations had significant effects on Tb.N (p < 0.0001). The largest difference in Tb.N (52%) was due to the method used to...Continue Reading

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Citations

Aug 4, 2007·The Journal of the Acoustical Society of America·D D Deligianni, K N Apostolopoulos
Dec 6, 2003·Radiology·Estela Martín-BadosaFrançoise Peyrin
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T HildebrandP Rüegsegger
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D BikleB Halloran
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laurent PothuaudSharmila Majumdar
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