Method for automatic adjustment of an insulin bolus calculator: in silico robustness evaluation under intra-day variability

Computer Methods and Programs in Biomedicine
Pau HerreroChristofer Toumazou

Abstract

Insulin bolus calculators are simple decision support software tools incorporated in most commercially available insulin pumps and some capillary blood glucose meters. Although their clinical benefit has been demonstrated, their utilisation has not been widespread and their performance remains suboptimal, mainly because of their lack of flexibility and adaptability. One of the difficulties that people with diabetes, clinicians and carers face when using bolus calculators is having to set parameters and adjust them on a regular basis according to changes in insulin requirements. In this work, we propose a novel method that aims to automatically adjust the parameters of a bolus calculator. Periodic usage of a continuous glucose monitoring device is required for this purpose. To test the proposed method, an in silico evaluation under real-life conditions was carried out using the FDA-accepted Type 1 diabetes mellitus (T1DM) UVa/Padova simulator. Since the T1DM simulator does not incorporate intra-subject variability and uncertainty, a set of modifications were introduced to emulate them. Ten adult and ten adolescent virtual subjects were assessed over a 3-month scenario with realistic meal variability. The glycaemic metrics: mean ...Continue Reading

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Citations

Aug 11, 2015·IEEE Journal of Biomedical and Health Informatics·Peter PeslPantelis Georgiou
May 9, 2016·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Sema CandemirGeorge Thoma
Jul 19, 2016·Computer Methods and Programs in Biomedicine·Mirko MessoriLalo Magni
Jul 26, 2017·Journal of Diabetes Science and Technology·John WalshLutz Heinemann
Jan 17, 2017·IEEE Transactions on Bio-medical Engineering·Chiara ToffaninClaudio Cobelli
Mar 2, 2018·Journal of Diabetes Science and Technology·Pau HerreroPantelis Georgiou
Feb 17, 2018·Journal of Diabetes Science and Technology·Roberto VisentinClaudio Cobelli
Feb 11, 2016·Journal of Diabetes Science and Technology·Peter PeslPantelis Georgiou
Oct 14, 2020·Diabetes Technology & Therapeutics·Parizad AvariMonika Reddy

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