Feb 1, 1976

Method for measuring hepatic uptake of oxygen or other blood-borne substances in situ

Journal of Applied Physiology
W W Lautt

Abstract

A preparation is described by which hepatic arterial blood flow and portal venous blood flow can be accurately and continuously measured while simultaneously providing a method by which multiple blood samples can be taken from the hepatic artery, portal vein, and hepatic vein without disrupting hepatic hemodynamics or causing hemodilution. By this means hepatic uptake or release of blood-borne substances can be measured in situ and correlated with hemodynamic parameters. In 13 splenectomized cats, oxygen uptake by the denervated liver was 4.5 +/- 0.3 ml . min-1. 100 g-1 of tissue, representing 54% of total oxygen removed by the splanchnic bed. The hepatic hemodynamics determined by this method are similar to those reported by others in vivo and the metabolic state of the liver remained stable for at least 2 h during which an average of 29 blood samples were taken. Advantages of this preparation over other methods of obtaining similar data are discussed.

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Mentioned in this Paper

Metabolic Process, Cellular
Dioxygen
Blood Flow Velocity
Structure of Hepatic Vein
Entire Portal Vein
Venous Blood Pressure
Entire Trunk of Portal Vein
Uptake
Portal Vein Structure
Hepatic

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